Long-Term Immunological Memory of SARS-CoV-2 Is Present in Patients with Primary Antibody Deficiencies for up to a Year after Vaccination

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dc.contributor.authorLucane, Zane
dc.contributor.authorSlisere, Baiba
dc.contributor.authorOzola, Lota
dc.contributor.authorRots, Dmitrijs
dc.contributor.authorPapirte, Sindija
dc.contributor.authorVilne, Baiba
dc.contributor.authorGailite, Linda
dc.contributor.authorKurjane, Natalja
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2023-03-27T09:10:01Z
dc.date.available2023-03-27T09:10:01Z
dc.date.issued2023-02-03
dc.descriptionFunding Information: This research was funded by the Latvian Council of Science project Nr.lzp-2020/1–0269. Publisher Copyright: © 2023 by the authors.
dc.description.abstractSome studies have found increased coronavirus disease-19 (COVID-19)-related morbidity and mortality in patients with primary antibody deficiencies. Immunization against COVID-19 may, therefore, be particularly important in these patients. However, the durability of the immune response remains unclear in such patients. In this study, we evaluated the cellular and humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in a cross-sectional study of 32 patients with primary antibody deficiency (n = 17 with common variable immunodeficiency (CVID) and n = 15 with selective IgA deficiency) and 15 healthy controls. Serological and cellular responses were determined using enzyme-linked immunosorbent assay and interferon-gamma release assays. The subsets of B and T lymphocytes were measured using flow cytometry. Of the 32 patients, 28 had completed the vaccination regimen with a median time after vaccination of 173 days (IQR = 142): 27 patients showed a positive spike-peptide-specific antibody response, and 26 patients showed a positive spike-peptide-specific T-cell response. The median level of antibody response in CVID patients (5.47 ratio (IQR = 4.08)) was lower compared to healthy controls (9.43 ratio (IQR = 2.13)). No difference in anti-spike T-cell response was found between the groups. The results of this study indicate that markers of the sustained SARS-CoV-2 spike-specific immune response are detectable several months after vaccination in patients with primary antibody deficiencies comparable to controls.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent921805
dc.format.extent921805
dc.identifier.citationLucane, Z, Slisere, B, Ozola, L, Rots, D, Papirte, S, Vilne, B, Gailite, L & Kurjane, N 2023, 'Long-Term Immunological Memory of SARS-CoV-2 Is Present in Patients with Primary Antibody Deficiencies for up to a Year after Vaccination', Vaccines, vol. 11, no. 2, 354. https://doi.org/10.3390/vaccines11020354
dc.identifier.doi10.3390/vaccines11020354
dc.identifier.issn2076-393X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/11227
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85149228249&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mdpi.com/2076-393X/11/2/354?type=check_update&version=1
dc.language.isoeng
dc.relation.ispartofVaccines
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantibody deficiency
dc.subjectantibody response
dc.subjectcommon variable immunodeficiency
dc.subjectimmune response
dc.subjectinborn error of immunity
dc.subjectSARS-CoV-2
dc.subjectselective IgA deficiency
dc.subjectT-cell response
dc.subject3.1 Basic medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectImmunology
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.subjectInfectious Diseases
dc.subjectPharmacology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleLong-Term Immunological Memory of SARS-CoV-2 Is Present in Patients with Primary Antibody Deficiencies for up to a Year after Vaccinationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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