Human bocavirus infection markers in peripheral blood and stool samples of children with acute gastroenteritis

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dc.contributor.authorNora-Krukle, Zaiga
dc.contributor.authorVilmane, Anda
dc.contributor.authorXu, Man
dc.contributor.authorRasa, Santa
dc.contributor.authorZiemele, Inga
dc.contributor.authorSilina, Elina
dc.contributor.authorSöderlund-Venermo, Maria
dc.contributor.authorGardovska, Dace
dc.contributor.authorMurovska, Modra
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionDepartment of Paediatrics
dc.date.accessioned2021-04-19T11:45:01Z
dc.date.available2021-04-19T11:45:01Z
dc.date.issued2018-11-15
dc.descriptionPublisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
dc.description.abstractHuman bocaviruses (HBoVs) 1–4 belong to the Parvoviridae family, and they infect the respiratory or gastrointestinal tracts in children. We investigated the prevalence of HBoV1–4 DNAs in the blood and stool samples, and of HBoV1–4 IgG and IgM in the plasma samples, of children presenting with acute gastroenteritis (AGE). In addition, we identified HBoV co-infections with the five most frequent gastrointestinal pathogens. A total of 83 paired blood and stool samples were collected from children aged five years or less. Infection markers of HBoV1, 2, or 3 (viral DNA in blood and/or stool and/or antibodies) were detected in 61 out of 83 (73.5%) patients. HBoV1, 2, or 3 DNA as a monoinfection was revealed in 18.1%, 2.4%, and 1.2%, respectively, and 21.7% in totalIn 56.1% of the HBoV DNA-positive patients, the presence in stool of another virus—most frequently norovirus or rotavirus—was observed. In conclusion, this study, for the first time, illustrates the prevalence and genetic diversity of HBoVs in Latvian children with gastroenteritis, and shows a widespread distribution of these viruses in the community. HBoV1 and 2 are commonly found as single infectious agents in children with AGE, suggesting that the viruses can be as pathogenic by themselves as other enteric agents are.en
dc.description.statusPeer reviewed
dc.format.extent243157
dc.identifier.citationNora-Krukle, Z, Vilmane, A, Xu, M, Rasa, S, Ziemele, I, Silina, E, Söderlund-Venermo, M, Gardovska, D & Murovska, M 2018, 'Human bocavirus infection markers in peripheral blood and stool samples of children with acute gastroenteritis', Viruses, vol. 10, no. 11, 639. https://doi.org/10.3390/v10110639
dc.identifier.doi10.3390/v10110639
dc.identifier.issn1999-4915
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3841
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85056729303&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofViruses
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute gastroenteritis
dc.subjectChildren
dc.subjectHuman bocavirus
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectInfectious Diseases
dc.subjectVirology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHuman bocavirus infection markers in peripheral blood and stool samples of children with acute gastroenteritisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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