Epidemiological and clinical characteristics of adult patients with chronic spontaneous urticaria in Latvia : insights from a two-centre study

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dc.contributor.authorSokolovskis, Artūrs
dc.contributor.authorLapiņa, Lāsma
dc.contributor.authorLauva, Anna
dc.contributor.authorPapirte, Sindija
dc.contributor.authorZolovs, Maksims
dc.contributor.authorCiekure, Līga
dc.contributor.authorMauliņš, Egīls
dc.contributor.authorLielmane, Līga
dc.contributor.authorKriķe, Petra
dc.contributor.authorSelicka, Marija
dc.contributor.authorPuriņa, Signe
dc.contributor.authorKurjāne, Nataļja
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2024-09-17T06:10:04Z
dc.date.available2024-09-17T06:10:04Z
dc.date.issued2024-07-01
dc.descriptionPublisher Copyright: © 2024 JLE.
dc.description.abstractBackground: Chronic spontaneous urticaria (CSU) significantly impacts the quality of life of affected individuals. Objectives: This study aimed to elucidate the epidemiological and clinical profiles of adult CSU patients in Latvia. Materials & Methods: Patient interviews and electronic medical records from two study centres in Riga, Latvia, were reviewed. PROMs, including UCT, UAS7, USS, and CU-Q2oL, were used to assess disease control, activity, severity, and quality of life. Statistical analysis was performed using Jamovi v. 2.3.28 and IBM SPSS v. 29.0.0.0. Results: The cohort included 140 CSU patients (76.4% female; mean age 41.3 ± 14.9 years), mostly urban residents (87.1%) and non-smokers (53.6%). Urticaria with angioedema occurred in 52.1% and isolated urticaria in 47.9%, with 40% experiencing CSU for 1-5 years. Accompanying symptoms were reported by 63% and triggers by 72.9%. Allergy history and autoimmune disease diagnosis were noted in 49.3% and 29.3%. Treatment mainly involved second-generation antihistamines (85.7%) and omalizumab (17.9%). Mean scores for USS, UCT, and UAS7 were 28.8 (SD: 17.8), 8.2 (SD: 3.7), and 17.2 (SD: 14.1). UAS7 indicated severe CSU in 28.6%, and UCT suggested poorly controlled disease in 77.9%. CU-Q2oL total scores revealed mental status as the most affected domain (mean score: 51.7, SD: 28.7), with a significant association between accompanying symptoms and questionnaire scores. Conclusion: This study provides insights into the demographic and clinical aspects of CSU patients in Latvia, highlighting areas for potential improvement in patient care and emphasizing the need for further investigation into treatment outcomes and patient quality of life.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent354917
dc.identifier.citationSokolovskis, A, Lapiņa, L, Lauva, A, Papirte, S, Zolovs, M, Ciekure, L, Mauliņš, E, Lielmane, L, Kriķe, P, Selicka, M, Puriņa, S & Kurjāne, N 2024, 'Epidemiological and clinical characteristics of adult patients with chronic spontaneous urticaria in Latvia : insights from a two-centre study', European Journal of Dermatology, vol. 34, no. 4, pp. 398-408. https://doi.org/10.1684/ejd.2024.4741
dc.identifier.doi10.1684/ejd.2024.4741
dc.identifier.issn1167-1122
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16678
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85202719299&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Dermatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectchronic spontaneous urticaria
dc.subjectclinical characteristics
dc.subjectdisease control
dc.subjectquality of life
dc.subject4.1 Agriculture, Forestry, and Fisheries
dc.subject4.3 Veterinary science
dc.subject1.6 Biological sciences
dc.subject3.3 Health sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectDermatology
dc.titleEpidemiological and clinical characteristics of adult patients with chronic spontaneous urticaria in Latvia : insights from a two-centre studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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