Cancer/testis antigens and gametogenesis : A review and "brain-storming" session

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dc.contributor.authorKalējs, Mārtiņš
dc.contributor.authorĒrenpreisa, Jekaterina
dc.date.accessioned2021-08-18T11:35:01Z
dc.date.available2021-08-18T11:35:01Z
dc.date.issued2005-02-16
dc.descriptionCopyright: Copyright 2005 Elsevier B.V., All rights reserved.
dc.description.abstractGenes expressed both in normal testis and in malignancies (Cancer/ Testis associated genes - CTA) have become the most extensively studied antigen group in the field of tumour immunology. Despite this, many fundamentally important questions remain unanswered: what is the connection between germ-cell specific genes and tumours? Is the expression of these genes yet another proof for the importance of genome destabilisation in the process of tumorigenesis?, or maybe activation of these genes is not quite random but instead related to some programme giving tumours a survival advantage? This review collates most of the recent information available about CTAs expression, function, and regulation. The data suggests a programme related to ontogenesis, mostly to gametogenesis. In the "brain-storming" part, facts in conflict with the hypothesis of random CTA gene activation are discussed. We propose a programme borrowed from organisms phylogenetically much older than humans, which existed before the differentiation of sexes. It is a programme that has served as a life cycle with prominent ploidy changes, and from which, as we know, the germ-cell ploidy cycle - meiosis - has evolved. Further work may show whether this hypothesis can lead to a novel antitumour strategy.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent3612434
dc.identifier.citationKalējs, M & Ērenpreisa, J 2005, 'Cancer/testis antigens and gametogenesis : A review and "brain-storming" session', Cancer Cell International, vol. 5, 4. https://doi.org/10.1186/1475-2867-5-4
dc.identifier.doi10.1186/1475-2867-5-4
dc.identifier.issn1475-2867
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6038
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=18144429106&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCancer Cell International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCTA genes
dc.subjectGametogenesis
dc.subjectPolyploidy
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGenetics
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCancer/testis antigens and gametogenesis : A review and "brain-storming" sessionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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