Autologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease : a double-blind randomized clinical trial

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dc.contributor.authorRodríguez Calvo-de-Mora, Marina
dc.contributor.authorDomínguez-Ruiz, Cayetano
dc.contributor.authorBarrero-Sojo, Francisco
dc.contributor.authorRodríguez-Moreno, Gustavo
dc.contributor.authorAntúnez Rodríguez, Cristina
dc.contributor.authorPonce Verdugo, Laura
dc.contributor.authorHernández Lamas, María del Carmen
dc.contributor.authorHernández-Guijarro, Luisa
dc.contributor.authorVillalvilla Castillo, Jacinto
dc.contributor.authorFernández-Baca Casares, Idefonso
dc.contributor.authorPrat Arrojo, Isidro
dc.contributor.authorBorroni, Davide
dc.contributor.authorAlba-Linero, Carmen
dc.contributor.authorZamorano-Martín, Francisco
dc.contributor.authorMoreno-Guerrero, Antonio
dc.contributor.authorRocha-de-Lossada, Carlos
dc.contributor.institutionDepartment of Doctoral Studies
dc.date.accessioned2023-11-22T11:35:01Z
dc.date.available2023-11-22T11:35:01Z
dc.date.issued2022-03
dc.descriptionFunding Information: The research work presented here has been funded through a grant awarded by the Ministry of Health within the framework of the Aid for Independent Clinical Research of 2011 (EC11‐506), whose promoter is the Andalusian Public Foundation for Research on Malaga in Biomedicine and Health (FIMABIS). Publisher Copyright: © 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
dc.description.abstractPurpose: To measure the effects of Autologous serum (AS), Allogeneic Serum (HS) and Umbilical Cord serum (CS) eye drops in severe dry eye disease (DES), as well as to characterize and quantify several molecules in the three sera (albumin, fibronectin; Vitamin A and E; IgG, IgA and IgM; Transforming growth factor β; Epithelial growth factor). Methods: Randomized, double-blind, single-centre, three-arm (AS, HS and CS) clinical trial. Sixty-three subjects were included with severe DES, 21 in each arm of the study. Visual acuity, Schirmer test, Breakup time (BUT), lissamine green, fluorescein staining measurements and a questionnaire were performed prior to treatment, and after one-month and three-month follow-up. Results: There was a significant main effect of time on visual acuities, Schirmer and BUT tests and fluorescein and lissamine green staining measurements and questionnaire scores (p = 0.015, p = 0.002, p < 0.001, p < 0.001, p = 0.031 and p < 0.001, respectively), although there was no significant interaction between time and serum type, nor between serum type and the test performed. Regarding the concentration of molecules, in our study AS contained significantly higher concentrations of IgA, IgG and fibronectin whereas HS contained significantly higher concentration of IgM, vitamins A and E, TGF and albumin. Contrary to previous reports, CS did not show higher concentration of any of the molecules analysed. Conclusions and relevance: The three sera were effective in the treatment of severe DES. CS did not contain a higher proportion of molecules compared to AS/HS. More research is needed to assess the effect of AS in patients with DES and autoimmune diseases.en
dc.description.statusPeer reviewed
dc.format.extent1818025
dc.identifier.citationRodríguez Calvo-de-Mora, M, Domínguez-Ruiz, C, Barrero-Sojo, F, Rodríguez-Moreno, G, Antúnez Rodríguez, C, Ponce Verdugo, L, Hernández Lamas, M D C, Hernández-Guijarro, L, Villalvilla Castillo, J, Fernández-Baca Casares, I, Prat Arrojo, I, Borroni, D, Alba-Linero, C, Zamorano-Martín, F, Moreno-Guerrero, A & Rocha-de-Lossada, C 2022, 'Autologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease : a double-blind randomized clinical trial', Acta Ophthalmologica, vol. 100, no. 2, pp. e396-e408. https://doi.org/10.1111/aos.14953
dc.identifier.doi10.1111/aos.14953
dc.identifier.issn1755-375X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14969
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85107931029&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofActa Ophthalmologica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectallogeneic serum eye drops
dc.subjectautoimmune disease
dc.subjectautologous serum eye drops
dc.subjectdry eye
dc.subjectgrowth factor
dc.subjecthaemoderivatives eye drops
dc.subjectocular surface
dc.subjectSjögren’s syndrome
dc.subjectumbilical cord serum eye drops
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOphthalmology
dc.titleAutologous versus allogeneic versus umbilical cord sera for the treatment of severe dry eye disease : a double-blind randomized clinical trialen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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