Streptococcus pneumoniae serotypes and factors associated with antimicrobial resistance in Invasive pneumococcal disease cases in Latvia, 2012–2022

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dc.contributor.authorSavrasova, Larisa
dc.contributor.authorVilleruša, Anita
dc.contributor.authorZeltiņa, Indra
dc.contributor.authorKrūmiņa, Angelika
dc.contributor.authorČupeca, Hedija
dc.contributor.authorBalasegaram, Sooria
dc.contributor.authorGrēve, Māra
dc.contributor.authorSavicka, Oksana
dc.contributor.authorSelderina, Solvita
dc.contributor.authorGalajeva, Jelena
dc.contributor.authorDushacka, Diana
dc.contributor.institutionInstitute of Public Health
dc.contributor.institutionDepartment of Infectology
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.contributor.institutionStatistics Unit
dc.date.accessioned2025-03-18T12:25:01Z
dc.date.available2025-03-18T12:25:01Z
dc.date.issued2025-03-12
dc.description.abstractBackground: Streptococcus pneumoniae is a major cause of Invasive pneumococcal disease (IPD), including bacteremic pneumonia, septicemia, and meningitis. The introduction of pneumococcal conjugate vaccines (PCVs) has significantly reduced the incidence of IPD caused by vaccine-covered serotypes. However, serotype replacement and antimicrobial resistance remain concerns. In Latvia, vaccination against pneumococcal disease was introduced into the NIP in 2010 with PCV7, later transitioning to PCV10 in 2012 and to PCV15 in 2024. This study aims is to determine the changes in S. pneumoniae antimicrobial resistance and its association with PCV10 serotypes in Latvia. Materials and methods: We conducted a population-based cross-sectional study using IPD surveillance data from Latvia over an 11-year period (2012–2022). IPD cases were defined according to the European Union case definition. Serotyping and antimicrobial susceptibility testing were performed on isolates from normally sterile sites. We analyzed the differences in IPD incidence, serotype distribution, and antimicrobial resistance using chi-square tests and multivariable logistic regression was used to determine associations between antimicrobial resistance and risk factors. Results: A total of 811 IPD cases were reported, with significant differences observed across the study period (p < 0.001). The most common serotypes were 3 and 19A. The proportion of IPD cases caused by PCV10 serotypes significantly decreased over the years, while cases caused by PCV13, PCV15, and PPPV23 serotypes increased. Antimicrobial susceptibility testing revealed resistance rates of 3.8% to penicillin, 5.4% to erythromycin, and 1.2% to cefotaxime/ceftriaxone. Erythromycin resistance showed significant variation over time (p = 0.016), decreasing from 7.1% in 2012 to 4.8% in 2022. Multivariable logistic regression indicated that IPD cases with S. pneumoniae PCV10 serotypes and meningitis were significantly associated with an increased likelihood of penicillin and erythromycin resistance. Conclusion: The study highlights a decrease in erythromycin resistance in IPD cases over time and significant associations between PCV10 serotypes and meningitis in IPD cases and penicillin and erythromycin resistance. The findings underscore the importance of continuous surveillance of S. pneumoniae serotypes and antimicrobial resistance patterns to inform treatment guidelines and vaccination policies. Further research is needed to assess the long-term impact of the PCV15 vaccine on S. pneumoniae serotype distribution and resistance.en
dc.description.statusPeer reviewed
dc.format.extent9
dc.format.extent1512336
dc.identifier.citationSavrasova, L, Villeruša, A, Zeltiņa, I, Krūmiņa, A, Čupeca, H, Balasegaram, S, Grēve, M, Savicka, O, Selderina, S, Galajeva, J & Dushacka, D 2025, 'Streptococcus pneumoniae serotypes and factors associated with antimicrobial resistance in Invasive pneumococcal disease cases in Latvia, 2012–2022', Frontiers in Public Health, vol. 13, 1501821. https://doi.org/10.3389/fpubh.2025.1501821
dc.identifier.doi10.3389/fpubh.2025.1501821
dc.identifier.issn2296-2565
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17182
dc.identifier.urlhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1501821/full
dc.language.isoeng
dc.relation.ispartofFrontiers in Public Health
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSreptococcus pneumoniae
dc.subjectLatvia
dc.subjectInvasive pneumococcal disease
dc.subjectantimicrobial resistance
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)
dc.titleStreptococcus pneumoniae serotypes and factors associated with antimicrobial resistance in Invasive pneumococcal disease cases in Latvia, 2012–2022en
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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