Hepatitis C virus infection epidemiology among people who inject drugs in Europe : a systematic review of data for scaling up treatment and prevention

Simple item page
dc.contributor.authorEMCDDA DRID group
dc.contributor.authorKarnīte, Anda
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-11-25T10:00:01Z
dc.date.available2021-11-25T10:00:01Z
dc.date.issued2014-07-28
dc.description.abstractBACKGROUND: People who inject drugs (PWID) are a key population affected by hepatitis C virus (HCV). Treatment options are improving and may enhance prevention; however access for PWID may be poor. The availability in the literature of information on seven main topic areas (incidence, chronicity, genotypes, HIV co-infection, diagnosis and treatment uptake, and burden of disease) to guide HCV treatment and prevention scale-up for PWID in the 27 countries of the European Union is systematically reviewed. METHODS AND FINDINGS: We searched MEDLINE, EMBASE and Cochrane Library for publications between 1 January 2000 and 31 December 2012, with a search strategy of general keywords regarding viral hepatitis, substance abuse and geographic scope, as well as topic-specific keywords. Additional articles were found through structured email consultations with a large European expert network. Data availability was highly variable and important limitations existed in comparability and representativeness. Nine of 27 countries had data on HCV incidence among PWID, which was often high (2.7-66/100 person-years, median 13, Interquartile range (IQR) 8.7-28). Most common HCV genotypes were G1 and G3; however, G4 may be increasing, while the proportion of traditionally 'difficult to treat' genotypes (G1+G4) showed large variation (median 53, IQR 43-62). Twelve countries reported on HCV chronicity (median 72, IQR 64-81) and 22 on HIV prevalence in HCV-infected PWID (median 3.9%, IQR 0.2-28). Undiagnosed infection, assessed in five countries, was high (median 49%, IQR 38-64), while of those diagnosed, the proportion entering treatment was low (median 9.5%, IQR 3.5-15). Burden of disease, where assessed, was high and will rise in the next decade. CONCLUSION: Key data on HCV epidemiology, care and disease burden among PWID in Europe are sparse but suggest many undiagnosed infections and poor treatment uptake. Stronger efforts are needed to improve data availability to guide an increase in HCV treatment among PWID.en
dc.description.statusPeer reviewed
dc.format.extent991514
dc.identifier.citationEMCDDA DRID group & Karnīte, A 2014, 'Hepatitis C virus infection epidemiology among people who inject drugs in Europe : a systematic review of data for scaling up treatment and prevention', PloS one, vol. 9, no. 7, pp. e103345. https://doi.org/10.1371/journal.pone.0103345
dc.identifier.doi10.1371/journal.pone.0103345
dc.identifier.issn1932-6203
dc.identifier.otherPubMedCentral: PMC4113410
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6880
dc.language.isoeng
dc.relation.ispartofPloS one
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComorbidity
dc.subjectEurope/epidemiology
dc.subjectEuropean Union/statistics & numerical data
dc.subjectHIV Infections/epidemiology
dc.subjectHepatitis C/drug therapy
dc.subjectHumans
dc.subjectIncidence
dc.subjectPrevalence
dc.subjectSubstance Abuse, Intravenous/epidemiology
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHepatitis C virus infection epidemiology among people who inject drugs in Europe : a systematic review of data for scaling up treatment and preventionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Hepatitis_C_Virus_Infection_Epidemiology_among_People_Who_Inject_Drugs_in_Europe.pdf
Size:
968.28 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure