Association of human parvovirus B19 infection with development and clinical course of myalgic encephalomyelitis / chronic fatigue syndrome : [Cilvēka parvovīrusa b19 infekcijas saistība ar mialģiskā encefalomielīta / hroniskā noguruma sindroma attīstību un klīnisko gaitu]
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Date
2019
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Abstract
Our aim was to estimate the presence of B19V infection markers, the level of cytokines and time period since the appearance of infection in association with ME/CFS clinical symptoms. In 200 ME/CFS patients and 104 control group individuals the presence of B19V-specific IgG/IgM class antibodies, B19V NS1 gene sequence, mRNA expression, viral load and level of cytokines were determined. B19V-specific IgG-antibodies were found in 70% of ME/CFS patients and 67.4% of controls, IgM-antibodies in 8% of patients and in none of controls, B19V genomic sequences in 29% of patients and 3.8% of controls. 58.6% of positive patients had active and 41.4% had latent/persistent B19V infection. B19V NS1 gene expression was detected in 43% of patients. B19V load varied from < 0.2 copies to median 38.2 copies/µg of DNA. According to the antibody pattern, 36% of patients had a recent, and 43% had sustained B19V infection. Patients with the B19V genomic sequence and NS1 specific antibodies significantly more often had lymphadenopathy and multi-joint pain. Onset of the symptoms corresponded to time of appearance of B19V infection. IL-10 and TNF- levels were higher in patients with elevated B19V load. B19V genome 1 was identified in Latvian ME/CFS patients. The results indicated that at least in some cases B19V infection plays an important role in ME/CFS development.
Description
Funding Information: This study was funded in parts by the projects: Taiwan–Latvia–Lithuania Cooperation Project “Establishing of the Framework to Track Molecular Epidemiology of Parvoviruses and to Correlate Sequence Variability with Different Clinical Manifestations” No. 6.2.-25/2013/0039. RSU ZP 13/2013 “Association of fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome with beta-herpesviruses (HHV-6A, HHV-6B, HHV-7) and parvovirus B19V infection”, “Support for doctoral study programs and research degrees RSU” (2009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009), and BALTINFECT “Unlocking infectious diseases research potential at Riga Stradins University” (Grant agreement No. 316275) within the European Union 7th Framework Programme. Publisher Copyright: © 2019 Sciendo. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
Keywords
Chronic fatigue syndrome, Human parvovirus B19, Myalgic encephalomyelitis, 1.6 Biological sciences, 3.2 Clinical medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General, SDG 3 - Good Health and Well-being
Citation
Rasa-Dzelzkalēja, S, Čapenko, S, Krūmiņa, A, Lin, Y C & Murovska, M 2019, 'Association of human parvovirus B19 infection with development and clinical course of myalgic encephalomyelitis / chronic fatigue syndrome : [Cilvēka parvovīrusa b19 infekcijas saistība ar mialģiskā encefalomielīta / hroniskā noguruma sindroma attīstību un klīnisko gaitu]', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 5, pp. 411-418. https://doi.org/10.2478/prolas-2019-0065