Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura

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dc.contributor.authorPlinta, Aelita
dc.contributor.authorTretjakovs, Pēteris
dc.contributor.authorSvirskis, Šimons
dc.contributor.authorLogina, Ināra
dc.contributor.authorGersone, Gita
dc.contributor.authorJurka, Antra
dc.contributor.authorMikelsone, Indra
dc.contributor.authorBlumfelds, Leons
dc.contributor.authorMackēvičs, Vitolds
dc.contributor.authorBahs, Guntis
dc.contributor.institutionFaculty of Medicine
dc.date.accessioned2022-10-14T07:55:01Z
dc.date.available2022-10-14T07:55:01Z
dc.date.issued2022-10
dc.descriptionPublisher Copyright: © 2022 by the authors.
dc.description.abstractThe aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α), and plasminogen activator inhibitor-1 (PAI-1) were measured. Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, and also with IFN-γ and MMP-9 only in patients with aura. There are three correlations in migraine patients with aura that are absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs without aura, on the other hand, have correlations that patients with aura do not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals.en
dc.description.statusPeer reviewed
dc.format.extent12
dc.format.extent32913734
dc.format.extent32913734
dc.identifier.citationPlinta, A, Tretjakovs, P, Svirskis, Š, Logina, I, Gersone, G, Jurka, A, Mikelsone, I, Blumfelds, L, Mackēvičs, V & Bahs, G 2022, 'Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura', Journal of Clinical Medicine, vol. 11, no. 19, 5696, pp. 1-12. https://doi.org/10.3390/jcm11195696
dc.identifier.doi10.3390/jcm11195696
dc.identifier.issn2077-0383
dc.identifier.otherMendeley: a49d6b5b-8d9c-371d-8142-b5aef676a28c
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9663
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85139761533&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleAssociation of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Auraen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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