Interconnected Pathways : Exploring Inflammation, Pain, and Cognitive Decline in Osteoarthritis

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dc.contributor.authorTarasovs, Mihails
dc.contributor.authorSkuja, Sandra
dc.contributor.authorSvirskis, Simons
dc.contributor.authorSokolovska, Lība
dc.contributor.authorVikmanis, Andris
dc.contributor.authorLejnieks, Aivars
dc.contributor.authorShoenfeld, Yehuda
dc.contributor.authorGroma, Valērija
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionJoint Laboratory of Electron Microscopy
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionDepartment of Orthopaedics
dc.date.accessioned2024-12-02T11:40:01Z
dc.date.available2024-12-02T11:40:01Z
dc.date.issued2024-11-06
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractThe relationship among inflammation, pain, and cognitive decline in osteoarthritis (OA) patients is complex and has not been sufficiently explored; therefore, we undertook this research to evaluate how OA-related inflammation and pain affect cognitive functions, as well as to examine the potential of urinary markers as indicators of these conditions. This study examined fifty OA patients through clinical and cognitive assessments, morphological analyses, urinary biomarkers, and bioinformatics. Morphologically, 24% of patients had moderate to high synovial inflammation, which was significantly correlated with depressive symptoms, pain intensity, and self-reported anxiety. The Montreal Cognitive Assessment indicated minimal decline in most patients but showed negative correlations with age and inflammation severity. Urinary TNF-α and TGF-β1 levels positively correlated with body mass index and pain and synovitis score and immune cell infiltration, respectively. In contrast, cartilage oligomeric matrix protein and C-telopeptides of type II collagen showed inverse correlations with pain duration and cognitive function, respectively. Distinct patient clusters with higher inflammation were identified and were associated with reported pain and depressive symptoms. Urinary TNF-α and TGF-β1 can serve as biomarkers reflecting inflammation and disease severity in OA. This study suggests that synovial inflammation may be linked to mental and cognitive health in some patient cohorts.en
dc.description.statusPeer reviewed
dc.format.extent22
dc.format.extent79753168
dc.identifier.citationTarasovs, M, Skuja, S, Svirskis, S, Sokolovska, L, Vikmanis, A, Lejnieks, A, Shoenfeld, Y & Groma, V 2024, 'Interconnected Pathways : Exploring Inflammation, Pain, and Cognitive Decline in Osteoarthritis', International Journal of Molecular Sciences, vol. 25, no. 22, 11918. https://doi.org/10.3390/ijms252211918, https://doi.org/10.3390/ijms252211918
dc.identifier.doi10.3390/ijms252211918
dc.identifier.issn1661-6596
dc.identifier.otherPubMedCentral: PMC11594107
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16940
dc.identifier.urlhttps://pubmed.ncbi.nlm.nih.gov/39595987/
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85210301093&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHumans
dc.subjectOsteoarthritis/complications
dc.subjectFemale
dc.subjectMale
dc.subjectCognitive Dysfunction/urine
dc.subjectInflammation/urine
dc.subjectMiddle Aged
dc.subjectBiomarkers/urine
dc.subjectAged
dc.subjectPain
dc.subjectTumor Necrosis Factor-alpha/metabolism
dc.subjectTransforming Growth Factor beta1/urine
dc.subjectDepression/etiology
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleInterconnected Pathways : Exploring Inflammation, Pain, and Cognitive Decline in Osteoarthritisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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