Distribution and Appearance of Ki-67, IL-1α, IL-10, and PGP 9.5 in Reinke’s Oedema-Affected Larynx Tissue Compared with Control Tissue

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dc.contributor.authorKonopecka, Vita
dc.contributor.authorPilmane, Māra
dc.contributor.authorSumerags, Dins
dc.contributor.authorSumeraga, Gunta
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-12-13T22:00:57Z
dc.date.available2021-12-13T22:00:57Z
dc.date.issued2021-12-10
dc.description.abstractSmoking, laryngopharyngeal reflux, and vocal fold abuse can promote the development of Reinke’s oedema, leading to vocal fold dysfunction and injury. The aim of the work was to investigate the appearance and distribution of proliferation marker Ki-67 (Ki-67), interleukin 10 (IL10), interleukin 1 alpha (IL-1α), and protein gene peptide 9.5 (PGP 9.5) in Reinke’s oedema-affected larynx tissue. Methods: A routine histological and immunohistochemical Reinke’s oedema and control group patient analysis was conducted. We used the biotin–streptavidin biochemical method to detect Ki-67, IL-10, IL-1α, and PGP 9.5 The semiquantitative grading method was used to evaluate immunoreactive cells' appearance and local distribution. A Mann–Whitney U test and Spearman’s rank coefficient were performed. Results: A low positive correlation between IL-1α epithelial and subepithelial immunoreactive cells in the patient group was found. Mann–Whitney U tests revealed significant patient and control group immunoreactive marker differences. All examined markers showed a higher number of immunoreactive structures in the patient group. Conclusions: Intensive proliferation of the surface epithelium was observed in patient tissues. The notable increase in IL10 positive structures indicates the dominant anti-inflammatory tissue response. An increased number of IL-1α structures in the larynx epithelium and subepithelium in the patient group is linked to inflammation, proliferation, and tissue remodelling. The PGP 9.5 expression increase is involved in the morphopathogenesis of Reinke’s oedema.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent1387394
dc.identifier.citationKonopecka, V, Pilmane, M, Sumerags, D & Sumeraga, G 2021, 'Distribution and Appearance of Ki-67, IL-1α, IL-10, and PGP 9.5 in Reinke’s Oedema-Affected Larynx Tissue Compared with Control Tissue', Life, vol. 11, no. 12, 1379. https://doi.org/10.3390/life11121379
dc.identifier.doi10.3390/life11121379
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7038
dc.identifier.urlhttps://doi.org/10.3390/life11121379
dc.language.isoeng
dc.relation.ispartofLife
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectReinke’s oedema
dc.subjectIL-10
dc.subjectIL-1α
dc.subjectKi-67
dc.subjectPGP 9.5
dc.subjectlarynx
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleDistribution and Appearance of Ki-67, IL-1α, IL-10, and PGP 9.5 in Reinke’s Oedema-Affected Larynx Tissue Compared with Control Tissueen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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