Time-dependent cytokine expression in bone of experimental animals after hydroxyapatite (Hap) implantation

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dc.contributor.authorPilmane, M.
dc.contributor.authorSalms, G.
dc.contributor.authorSalma, I.
dc.contributor.authorSkagers, A.
dc.contributor.authorLocs, J.
dc.contributor.authorLoca, D.
dc.contributor.authorBerzina-Cimdina, L.
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.contributor.institutionDepartment of Oral and Maxillofacial Surgery and Oral Medicine
dc.date.accessioned2021-04-28T08:40:01Z
dc.date.available2021-04-28T08:40:01Z
dc.date.issued2011
dc.description.abstractProinflammatory cytokines mediate bone loss around the implants in patients with peri-implant disease. However, there is no complete data about the expression of cytokines into the bone around the implants. The aim of this work was to investigate the distribution and appearance of inflammatory cytokines and anti-inflammatory proteins in the bone of jaw of experimental rabbits in different time periods after HAp implantation. Material was obtained from 8 rabbits in lower jaw 6 and 8 months after HAp implants were placed. Tissues were processed for immunohistochemical detection of tumor necrosis factor alfa (TNFα), Interleukin 1, 6, 8, 10 (IL-1, IL-6, IL-8, IL-10) and defensin 2. Results demonstrated practically unchanged expression of IL-6 and IL-10 between both - experimental and control side 6 months after implantation, while IL-1 and IL-8 notably increased in control side. IL-1 and IL-10 expression did not change in either the experimental side nor the controle side after 8 months HAP implantation, but IL-6 and IL-8 demonstrated a decrease in the control sites. Only IL-8 was elevated with time in experimental sites, while IL-10 showed individual variations in 2 cases.en
dc.description.statusPeer reviewed
dc.format.extent870912
dc.identifier.citationPilmane, M, Salms, G, Salma, I, Skagers, A, Locs, J, Loca, D & Berzina-Cimdina, L 2011, Time-dependent cytokine expression in bone of experimental animals after hydroxyapatite (Hap) implantation. in International Conference "Functional Materials and Nanotechnologies" (FM &NT-2011) : Conference Proceedings. 1 edn, vol. 23, 012022, IOP Conference Series: Materials Science and Engineering, International Conference "Functional Materials and Nanotechnologies" (FM &NT-2011), Riga, Latvia, 5/04/11. https://doi.org/10.1088/1757-899X/23/1/012022
dc.identifier.citationconference
dc.identifier.doi10.1088/1757-899X/23/1/012022
dc.identifier.issn1757-8981
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3956
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=80052000323&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Conference "Functional Materials and Nanotechnologies" (FM&NT-2011)
dc.relation.ispartofseriesIOP Conference Series: Materials Science and Engineering
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject2.5 Materials engineering
dc.subject2.6 Medical engineering
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database
dc.subjectGeneral Materials Science
dc.subjectGeneral Engineering
dc.titleTime-dependent cytokine expression in bone of experimental animals after hydroxyapatite (Hap) implantationen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontobookanthology/conference

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