Pharmacological properties of polyphenols : Bioavailability, mechanisms of action and biological effects in in vitro studies, animal models and humans

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dc.contributor.authorStromsnes, Kristine
dc.contributor.authorLagzdiņa, Rudīte
dc.contributor.authorOlaso‐Gonzalez, Gloria
dc.contributor.authorGimeno‐Mallench, Lucia
dc.contributor.authorGambini, Juan
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2021-11-29T07:30:01Z
dc.date.available2021-11-29T07:30:01Z
dc.date.issued2021-08
dc.descriptionFunding Information: Funding: This work was supported by the following grants from the Instituto de Salud Carlos III CB16/10/00435 (CIBERFES), (PID2019‐110906RB‐I00/AEI/10.13039/501100011033) from the Spanish Ministry of Innovation and Science, PROMETEO/2019/097 de “Consellería, de Sanitat de la Gener‐ alitat Valenciana”, and the EU Funded H2020‐DIABFRAIL‐LATAM (Ref: 825546), European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL), and of the ERA‐NET Co‐ fund ERA‐HDHL (GA No. 696295 of the EU Horizon 2020 Research and Innovation Program). Part of the equipment employed in this work has been funded by Generalitat Valenciana and co‐financed with ERDF funds (OP ERDF of Comunitat Valenciana 2014–2020). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractDrugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.en
dc.description.statusPeer reviewed
dc.format.extent26
dc.format.extent34846705
dc.identifier.citationStromsnes, K, Lagzdiņa, R, Olaso‐Gonzalez, G, Gimeno‐Mallench, L & Gambini, J 2021, 'Pharmacological properties of polyphenols : Bioavailability, mechanisms of action and biological effects in in vitro studies, animal models and humans', Biomedicines , vol. 9, no. 8, 1074. https://doi.org/10.3390/biomedicines9081074
dc.identifier.doi10.3390/biomedicines9081074
dc.identifier.issn2227-9059
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6899
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85113377731&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBiomedicines
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBioavailability
dc.subjectBiological effects
dc.subjectConcomitant
dc.subjectDrugs
dc.subjectHuman
dc.subjectIn vitro
dc.subjectIn vivo
dc.subjectMechanisms of action
dc.subjectPharmacological
dc.subjectPolyphenol
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePharmacological properties of polyphenols : Bioavailability, mechanisms of action and biological effects in in vitro studies, animal models and humansen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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