Immunological Aspects of EBV and Oral Mucosa Interactions in Oral Lichen Planus

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dc.contributor.authorČēma, Ingrīda
dc.contributor.authorKakar, Jagriti
dc.contributor.authorDzudzilo, Madara
dc.contributor.authorMurovska, Modra
dc.contributor.institutionDepartment of Oral and Maxillofacial Surgery and Oral Medicine
dc.contributor.institutionDepartment of Doctoral Studies
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2023-08-02T14:55:01Z
dc.date.available2023-08-02T14:55:01Z
dc.date.issued2023-06-01
dc.descriptionFunding Information: VirA project Nr. 952376. Publisher Copyright: © 2023 by the authors.
dc.description.abstractOral lichen planus (OLP) is considered a T cell-mediated chronic inflammatory process activated by an unknown antigen, making basal keratinocytes vulnerable to a cytotoxic cell mediated immune response. The aim of this review is to summarize information on the role and pathways of Epstein–Barr virus (EBV) and immune cells in inducing OLP as an autoimmune lesion. The pathogenesis of OLP is analyzed from immunological aspects of interactions between EBV and oral mucosa. The results of the available studies allow us to assume that EBV can act both as an exogenous and an endogenous antigen in the pathogenesis of OLP. We emphasized the role of antigen-presenting cells (APC), such as dendritic cells (Langerhans cells, LC), in detecting and capturing antigens and modulating the adaptive immune response. Although EBV shows tropism for B cells and epithelial cells, under certain conditions it can infect monocytes, LCs, NK, and T lymphocytes. It means that under some circumstances of the chronic inflammatory process, EBV particles can react as endogenous agents. During the development of the autoimmune process, a decisive role is played by the loss of immune tolerance. Factors like the activity of cytokines, chemokines, and autoantibodies secreted by EBV-positive plasma cells, autoantigens formed due to virus protein mimicry of human proteins, new self-peptides released from damaged tissues, self-reactive B and T cells, dysregulation of LC function, the anti-apoptotic effect of EBV early lytic antigens, and an imbalance between inflammatory and anti-inflammatory immune cells facilitate the development of an autoimmune process.en
dc.description.statusPeer reviewed
dc.format.extent17
dc.format.extent790185
dc.identifier.citationČēma, I, Kakar, J, Dzudzilo, M & Murovska, M 2023, 'Immunological Aspects of EBV and Oral Mucosa Interactions in Oral Lichen Planus', Applied Sciences (Switzerland), vol. 13 , no. 11, 6735. https://doi.org/10.3390/app13116735
dc.identifier.doi10.3390/app13116735
dc.identifier.issn2076-3417
dc.identifier.otherMendeley: 4dcfcd32-d241-37aa-bd48-5dbea9fd6aae
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14272
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85163136375&partnerID=8YFLogxK
dc.identifier.urlhttps://www.mendeley.com/catalogue/4dcfcd32-d241-37aa-bd48-5dbea9fd6aae/
dc.language.isoeng
dc.relation.ispartofApplied Sciences (Switzerland)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectoral lichen planus
dc.subjectEpstein–Barr virus
dc.subjectchronic inflammation
dc.subjectoral epithelia
dc.subjectdendritic cells
dc.subjectimmune cells
dc.subjectautoimmunity
dc.subject3.1 Basic medicine
dc.subject3.5 Other medical sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Engineering
dc.subjectInstrumentation
dc.subjectGeneral Materials Science
dc.subjectFluid Flow and Transfer Processes
dc.subjectProcess Chemistry and Technology
dc.subjectComputer Science Applications
dc.titleImmunological Aspects of EBV and Oral Mucosa Interactions in Oral Lichen Planusen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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