Reduced GFAP expression in Bergmann glial cells in the cerebellum of sigma-1 receptor knockout mice determines the neurobehavioral outcomes after traumatic brain injury

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dc.contributor.authorStelfa, Gundega
dc.contributor.authorVāvers, Edijs
dc.contributor.authorSvalbe, Baiba
dc.contributor.authorSerzants, Rinalds
dc.contributor.authorMiteniece, Anna
dc.contributor.authorLauberte, Lasma
dc.contributor.authorGrinberga, Solveiga
dc.contributor.authorGukalova, Baiba
dc.contributor.authorDambrova, Maija
dc.contributor.authorZvejniece, Liga
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2021-11-10T13:50:01Z
dc.date.available2021-11-10T13:50:01Z
dc.date.issued2021-11-01
dc.descriptionFunding Information: Funding: This study was supported by EU-ERA-NET NEURON project TRAINS No. 9642151 and the European Union’s Horizon 2020 research and innovation program under grant agreement No. 857394. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractNeuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate the role of S1R in the development of neurological deficits after TBI. Adult male wild-type CD-1 (WT) and S1R knockout (S1R-/-) mice were subjected to lateral fluid percussion injury, and behavioral and histological outcomes were assessed for up to 12 months postinjury. Neurological deficits and motor coordination impairment were less pronounced in S1R-/-mice with TBI than in WT mice with TBI 24 h after injury. TBI-induced short-term memory impairments were present in WT but not S1R-/-mice 7 months after injury. Compared to WT animals, S1R-/-mice exhibited better motor coordination and less pronounced despair behavior for up to 12 months postinjury. TBI induced astrocyte activation in the cortex of WT but not S1R-/-mice. S1R-/-mice presented a significantly reduced GFAP expression in Bergmann glial cells in the molecular layer of the cerebellum compared to WT mice. Our findings suggest that S1R deficiency reduces TBI-induced motor coordination impairments by reducing GFAP expression in Bergmann glial cells in the cerebellum.en
dc.description.statusPeer reviewed
dc.format.extent39928777
dc.identifier.citationStelfa, G, Vāvers, E, Svalbe, B, Serzants, R, Miteniece, A, Lauberte, L, Grinberga, S, Gukalova, B, Dambrova, M & Zvejniece, L 2021, 'Reduced GFAP expression in Bergmann glial cells in the cerebellum of sigma-1 receptor knockout mice determines the neurobehavioral outcomes after traumatic brain injury', International Journal of Molecular Sciences, vol. 22, no. 21, 11611. https://doi.org/10.3390/ijms222111611
dc.identifier.doi10.3390/ijms222111611
dc.identifier.issn1661-6596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6812
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85117923613&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAstrocytes
dc.subjectCerebellum
dc.subjectLateral fluid percussion injury
dc.subjectNeurobehavior
dc.subjectSigma-1 receptor
dc.subjectTraumatic brain injury
dc.subject1.4 Chemical sciences
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleReduced GFAP expression in Bergmann glial cells in the cerebellum of sigma-1 receptor knockout mice determines the neurobehavioral outcomes after traumatic brain injuryen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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