Immunohistochemical Profile of Parathyroid Tumours : A Comprehensive Review

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dc.contributor.authorUljanovs, Romans
dc.contributor.authorSinkarevs, Stanislavs
dc.contributor.authorStrumfs, Boriss
dc.contributor.authorVidusa, Liga
dc.contributor.authorMerkurjeva, Kristīne
dc.contributor.authorStrumfa, Ilze
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2022-10-06T12:55:01Z
dc.date.available2022-10-06T12:55:01Z
dc.date.issued2022-07
dc.descriptionPublisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractImmunohistochemistry remains an indispensable tool in diagnostic surgical pathology. In parathyroid tumours, it has four main applications: to detect (1) loss of parafibromin; (2) other manifestations of an aberrant immunophenotype hinting towards carcinoma; (3) histogenesis of a neck mass and (4) pathogenetic events, including features of tumour microenvironment and immune landscape. Parafibromin stain is mandatory to identify the new entity of parafibromin-deficient parathyroid neoplasm, defined in the WHO classification (2022). Loss of parafibromin indicates a greater probability of malignant course and should trigger the search for inherited or somatic CDC73 mutations. Aberrant immunophenotype is characterised by a set of markers that are lost (parafibromin), down-regulated (e.g., APC protein, p27 protein, calcium-sensing receptor) or upregulated (e.g., proliferation activity by Ki-67 exceeding 5%) in parathyroid carcinoma compared to benign parathyroid disease. Aberrant immunophenotype is not the final proof of malignancy but should prompt the search for the definitive criteria for carcinoma. Histogenetic studies can be necessary for differential diagnosis between thyroid vs. parathyroid origin of cervical or intrathyroidal mass; detection of parathyroid hormone (PTH), chromogranin A, TTF-1, calcitonin or CD56 can be helpful. Finally, immunohistochemistry is useful in pathogenetic studies due to its ability to highlight both the presence and the tissue location of certain proteins. The main markers and challenges (technological variations, heterogeneity) are discussed here in the light of the current WHO classification (2022) of parathyroid tumours.en
dc.description.statusPeer reviewed
dc.format.extent25
dc.format.extent977061
dc.identifier.citationUljanovs, R, Sinkarevs, S, Strumfs, B, Vidusa, L, Merkurjeva, K & Strumfa, I 2022, 'Immunohistochemical Profile of Parathyroid Tumours : A Comprehensive Review', International Journal of Molecular Sciences, vol. 23, no. 13, 6981. https://doi.org/10.3390/ijms23136981
dc.identifier.doi10.3390/ijms23136981
dc.identifier.issn1661-6596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9642
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85132363678&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectatypical parathyroid tumour
dc.subjectcalcium-sensing receptor
dc.subjectimmunohistochemistry
dc.subjectKi-67
dc.subjectmultiglandular parathyroid disease
dc.subjectp27
dc.subjectparafibromin
dc.subjectparathyroid adenoma
dc.subjectparathyroid carcinoma
dc.subjecttumour microenvironment
dc.subjectWHO classification
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleImmunohistochemical Profile of Parathyroid Tumours : A Comprehensive Reviewen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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