Repeatability of magnetic resonance measurements used for estimating Crohn's disease activity

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dc.contributor.authorApine, Ilze
dc.contributor.authorPirksta, Ieva
dc.contributor.authorPitura, Reinis
dc.contributor.authorPokrotnieks, Juris
dc.contributor.authorPuķīte, Ieva
dc.contributor.authorKrūmiņa, Gaida
dc.contributor.institutionDepartment of Radiology
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-08-27T13:10:04Z
dc.date.available2021-08-27T13:10:04Z
dc.date.issued2020-04-01
dc.descriptionPublisher Copyright: © 2020 Sciendo. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractThe MR activity indices used for quantification and follow-up of Crohn's disease are composed of a number of subjectively determinable components with equivocal repeatability. The purpose of this article was to assess the repeatability of measurements used for quantitative estimation of Crohn's disease activity in the terminal ileum. In five adults (23-57 y.o.) and 12 children (10-17 y.o.) with active terminal ileitis, the inflamed bowel was divided into 3 cm segments (n = 32 in adults, n = 46 in children), and measurements for the calculation of MaRIA and Clermont scores were performed. Parameters included apparent diffusion coefficients (ADC) for diffusion-weighted imaging (DWI) sequences with selective and non-selective fat suppression, wall signal enhancement before (WSI-preGd) and after (WSI-preGd) gadolinium enhancement, bowel thickness, and presence of ulcers. The measurements were standardised (accurate site-to-site comparison, exact ROI size, where applicable) and repeated by the same researcher after two months. Intra-observer agreement for ADC, WSI-preGd and WSI-postGd, bowel thickness was assessed with a paired t-test, and the significant difference in presence/absence of ulcers was assessed by the Pearson 2 test. Absolute difference was not found between the 1st and 2nd measurements of ADC, WSI-preGd, WSI-postGd and wall thickness. There was systematic difference in the presence of bowel ulcers. In standardised conditions the repeatability of ADC, WSI-preGd and WSI-postGd is high. Efforts must be made to precisely define the size and appearance of ulcers that may be included in the index calculation.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent1310959
dc.identifier.citationApine, I, Pirksta, I, Pitura, R, Pokrotnieks, J, Puķīte, I & Krūmiņa, G 2020, 'Repeatability of magnetic resonance measurements used for estimating Crohn's disease activity', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 74, no. 2, pp. 75-82. https://doi.org/10.2478/prolas-2020-0012
dc.identifier.doi10.2478/prolas-2020-0012
dc.identifier.issn1407-009X
dc.identifier.otherunpaywall: 10.2478/prolas-2020-0012
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6115
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85086050699&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectActivity indices
dc.subjectClermont score
dc.subjectIntra-observer agreement
dc.subjectMagnetic resonance enterography
dc.subjectMaRIA
dc.subjectTerminal ileitis
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleRepeatability of magnetic resonance measurements used for estimating Crohn's disease activityen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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