Possible Relation of Roseolovirus Infection with Fibromyalgia

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dc.contributor.authorCapenko, Svetlana
dc.contributor.authorMihailova, Marija
dc.contributor.authorRasa, Santa
dc.contributor.authorKrūminą, Angelika
dc.contributor.authorZazerska, Zane
dc.contributor.authorLogina, Inara
dc.contributor.authorMurovska, Modra
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.contributor.institutionInstitute of Microbiology and Virology
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2021-04-20T13:40:01Z
dc.date.available2021-04-20T13:40:01Z
dc.date.issued2016-08-01
dc.descriptionPublisher Copyright: © 2016 by Svetlana Capenko. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.
dc.description.abstractFibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and-7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses potentially pathogenic to the nervous system. Presence of anti-HHV-6 and-HHV-7 antibodies and viral genomic sequences, viral loads, HHV-6 variant-specificity, and TNF-α level were studied in 41 FM patients and 50 healthy individuals using polymerase chain reactions, restriction endonuclease analysis and ELISA. There was no difference in the presence of anti-HHV-6 and anti-HHV-7 IgG class antibodies between FM patients and control group individuals. Viral sequences were found in 80.5% of FM patients and in 62.0% of controls. Significantly higher rate of concurrent HHV-6 and HHV-7 infection and higher viral loads in peripheral blood were detected in FM patients compared to the control group individuals. Plasma viremia was detected only in FM patients. Significantly higher TNF-α levels were detected in virus positive FM patients. From all positive cases only in two FM patients HHV-6A was revealed. Significantly higher detection frequency of concurrent HHV-6 and HHV-7 infection, simultaneous HHV-6 and HHV-7 activation, higher viral loads and TNF-α expression levels in primary FM patients than in control group individuals indicate the potential involvement of Roseoloviruses in development of this disorder.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent85455
dc.identifier.citationCapenko, S, Mihailova, M, Rasa, S, Krūminą, A, Zazerska, Z, Logina, I & Murovska, M 2016, 'Possible Relation of Roseolovirus Infection with Fibromyalgia', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 70, no. 4, pp. 205-210. https://doi.org/10.1515/prolas-2016-0032
dc.identifier.doi10.1515/prolas-2016-0032
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3873
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84983456649&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfibromyalgia
dc.subjecthuman herpesvirus-6
dc.subjecthuman herpesvirus-7
dc.subjectinfection
dc.subjectmolecular diagnostic
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePossible Relation of Roseolovirus Infection with Fibromyalgiaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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