Clinical characterisation of rota virus infection associated with most commonly circulating genotypes in children hospitalised in children's university hospital : A cross-sectional study in Latvia

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dc.contributor.authorLaizane, Gunta
dc.contributor.authorĶīvīte-Urtāne, Anda
dc.contributor.authorGrope, Ilze
dc.contributor.authorSmane, Liene
dc.contributor.authorMiklaševičs, Edvīns
dc.contributor.authorOzoliņa, Laura
dc.contributor.authorGardovska, Dace
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionDepartment of Public Health and Epidemiology
dc.contributor.institutionDepartment of Biology and Microbiology
dc.contributor.institutionOnkoloģijas institūts
dc.date.accessioned2021-04-12T12:25:01Z
dc.date.available2021-04-12T12:25:01Z
dc.date.issued2019
dc.description.abstractIn developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children's Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age < 5 years, G4P[8] (45.5%), G2P[4] (18.2%), G9P[8], G3P[8], and G1P[8] (9.1%) in children of age > 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.en
dc.description.statusPeer reviewed
dc.format.extent103723
dc.identifier.citationLaizane, G, Ķīvīte-Urtāne, A, Grope, I, Smane, L, Miklaševičs, E, Ozoliņa, L & Gardovska, D 2019, 'Clinical characterisation of rota virus infection associated with most commonly circulating genotypes in children hospitalised in children's university hospital : A cross-sectional study in Latvia', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 4, pp. 312-316. https://doi.org/10.2478/prolas-2019-0049
dc.identifier.doi10.2478/prolas-2019-0049
dc.identifier.issn1407-009X
dc.identifier.otherresearchoutputwizard: 3F21E384-B35A-452B-AA4D-18FB18B8C004
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3759
dc.identifier.urlhttps://content.sciendo.com/view/journals/prolas/73/4/article-p312.xml?lang=en
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectrotavirus
dc.subjectgastroenteritis
dc.subjectgenotyping
dc.subjectchildren
dc.subjectclinical characterisation
dc.subject1.6 Biological sciences
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleClinical characterisation of rota virus infection associated with most commonly circulating genotypes in children hospitalised in children's university hospital : A cross-sectional study in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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