Dry Eye Para-Inflammation Treatment : Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisone

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dc.contributor.authorBorroni, Davide
dc.contributor.authorMazzotta, Cosimo
dc.contributor.authorRocha-de-Lossada, Carlos
dc.contributor.authorSánchez-González, José María
dc.contributor.authorBallesteros-Sanchez, Antonio
dc.contributor.authorGarcía-Lorente, María
dc.contributor.authorZamorano-Martín, Francisco
dc.contributor.authorSpinelli, Antonio
dc.contributor.authorSchiano-Lomoriello, Domenico
dc.contributor.authorTedesco, Giovanni Roberto
dc.date.accessioned2025-01-02T09:55:01Z
dc.date.available2025-01-02T09:55:01Z
dc.date.issued2023-12
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractPurpose: The purpose of this study was to check the efficacy and safety of a novel tear substitute containing hyaluronic acid and low-dose hydrocortisone in the treatment of moderate dry eye disease. Methods: In this prospective randomized study, 38 patients with moderate dry eye disease were divided into two treatment groups: Group 1 received one drop of 0.2% sodium hyaluronate and 0.001% hydrocortisone four times daily for 3 months, while Group 2 received 0.15% sodium hyaluronate and 3% trehalose at the same dosage. OSDI and SANDE questionnaires, Non-Invasive Break-Up time (NIBUT), Tear Meniscus Height (TMH), meibography, Lipid Layer Thickness (LLT), Tear Break-Up Time (TBUT), Corneal Staining Score (CFS), and Intraocular Pressure (IOP) were evaluated at baseline and after 1, 2, and 3 months of treatment. Results: During the treatment period, Group 1 showed statistically significant improvement in OSDI score (p = 0.002), SANDE score (p = 0.01), NIBUT (p < 0.0001), LLT (p < 0.0001), TBUT (p = 0.01), and CFS (p = 0.02). In Group 2, significant improvement was observed only in the TBUT score (p < 0.05). Comparison of the two groups showed that NIBUT and LLT were significantly different at the end of treatment (p = 0.001 for both comparisons), with more favorable results for sodium hyaluronate and hydrocortisone than for sodium hyaluronate and trehalose. No significant variations in intraocular pressure were observed in either group during the treatment period (p > 0.05). Conclusions: The study confirms that a 3-months treatment with hyaluronic acid 0.2% in combination with low-dose hydrocortisone 0.001% improves the signs and symptoms of moderate DED and that a low-dosage 0.001% hydrocortisone can be helpful in preventing the progression to chronic stages of DED.en
dc.description.statusPeer reviewed
dc.format.extent622258
dc.identifier.citationBorroni, D, Mazzotta, C, Rocha-de-Lossada, C, Sánchez-González, J M, Ballesteros-Sanchez, A, García-Lorente, M, Zamorano-Martín, F, Spinelli, A, Schiano-Lomoriello, D & Tedesco, G R 2023, 'Dry Eye Para-Inflammation Treatment : Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisone', Biomedicines , vol. 11, no. 12, 3277. https://doi.org/10.3390/biomedicines11123277
dc.identifier.doi10.3390/biomedicines11123277
dc.identifier.issn2227-9059
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16995
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85180515582&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBiomedicines
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcorticosteroids
dc.subjectdry eye disease
dc.subjecthyaluronic acid
dc.subjecthydrocortisone
dc.subjectpara-inflammation
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.titleDry Eye Para-Inflammation Treatment : Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisoneen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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