HPV Type Distribution in Benign, High-Grade Squamous Intraepithelial Lesions and Squamous Cell Cancers of the Anus by HIV Status

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dc.contributor.authorChowdhury, Sona
dc.contributor.authorDarragh, Teresa M.
dc.contributor.authorBerry-Lawhorn, J. Michael
dc.contributor.authorIsaguliants, Maria G.
dc.contributor.authorVonsky, Maxim S.
dc.contributor.authorHilton, Joan F.
dc.contributor.authorLazar, Ann A.
dc.contributor.authorPalefsky, Joel M.
dc.contributor.institutionInstitute of Microbiology and Virology
dc.date.accessioned2024-02-29T09:13:36Z
dc.date.available2024-02-29T09:13:36Z
dc.date.issued2023-02
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractThe incidence of anal cancer is increasing, especially in high-risk groups, such as PLWH. HPV 16, a high-risk (HR) HPV genotype, is the most common genotype in anal high-grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) in the general population. However, few studies have described the distribution of HR HPV genotypes other than HPV 16 in the anus of PLWH. HPV genotyping was performed by DNA amplification followed by dot-blot hybridization to identify the HR and low-risk (LR) genotypes in benign anal lesions (n = 34), HSIL (n = 30), and SCC (n = 51) of PLWH and HIV-negative individuals. HPV 16 was the most prominent HR HPV identified, but it was less common in HSIL and SCC from PLWH compared with HIV-negative individuals, and other non-HPV 16 HR HPV (non-16 HR HPV) types were more prevalent in samples from PLWH. A higher proportion of clinically normal tissues from PLWH were positive for one or more HPV genotypes. Multiple HPV infection was a hallmark feature for all tissues (benign, HSIL, SCC) of PLWH. These results indicate that the development of anal screening approaches based on HPV DNA testing need to include non-16 HR HPVs along with HPV 16, especially for PLWH. Along with anal cytology, these updated screening approaches may help to identify and prevent anal disease progression in PLWH.en
dc.description.statusPeer reviewed
dc.format.extent2873020
dc.identifier.citationChowdhury, S, Darragh, T M, Berry-Lawhorn, J M, Isaguliants, M G, Vonsky, M S, Hilton, J F, Lazar, A A & Palefsky, J M 2023, 'HPV Type Distribution in Benign, High-Grade Squamous Intraepithelial Lesions and Squamous Cell Cancers of the Anus by HIV Status', Cancers, vol. 15, no. 3, 660. https://doi.org/10.3390/cancers15030660
dc.identifier.doi10.3390/cancers15030660
dc.identifier.issn2072-6694
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15349
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85147810620&partnerID=8YFLogxK
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:000933804800001?SID=EUW1ED0EDFBvewh5ycMpDjh8yVaFR
dc.language.isoeng
dc.relation.ispartofCancers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanal cancer
dc.subjectHIV-negative
dc.subjectHPV 16
dc.subjectHPV genotypes
dc.subjectHPV screening
dc.subjectHSIL
dc.subjectPLWH
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHPV Type Distribution in Benign, High-Grade Squamous Intraepithelial Lesions and Squamous Cell Cancers of the Anus by HIV Statusen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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