Rubeosis faciei diabeticorum is not associated with oxidative stress and skin autofluorescence

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dc.contributor.authorZavorins, Aleksejs
dc.contributor.authorSilova, Alise
dc.contributor.authorVoicehovska, Julija
dc.contributor.authorKisis, Janis
dc.contributor.institutionDepartment of Dermatology and Venereology
dc.contributor.institutionBioķīmijas zinātniskā laboratorija
dc.contributor.institutionDepartment of Internal Diseases
dc.date.accessioned2021-05-10T12:10:01Z
dc.date.available2021-05-10T12:10:01Z
dc.date.issued2019-09-01
dc.descriptionFunding Information: Riga Stradins University, Doctoral Studies Grant. Publisher Copyright: © 2019
dc.description.abstractBackground: Rubeosis faciei diabeticorum is a persistent facial erythema in patients with diabetes mellitus. The actual pathogenesis has not been studied. However, it is speculated to be a cutaneous diabetic microangiopathy. Objective: Examine the correlation between the severity of facial erythema and the possible causes of microvascular diabetic complications, namely oxidative stress, hyperglycemia, and cutaneous accumulation of advanced glycation end-products. Methods: Patients diagnosed with Type 2 diabetes mellitus (n = 32) were enrolled in the study. The facial erythema index was measured using the Mexameter MX18; cutaneous accumulation of advanced glycation end-products was estimated by measuring skin auto fluorescence with the AGE Reader (DiagnOptics Technologies B.V. – Groningen, Netherlands). Glycated haemoglobin, total antioxidant status, and malondialdehyde were measured in blood by TBARS assay. The correlation between the selected variables was assessed by Spearman's rank test; p ≤ 0.05 was considered statistically significant. Results: There was a statistically significant correlation between total antioxidant status and the facial erythema index (ρ = 0.398, p = 0.024). Malondialdehyde, skin autofluorescence, glycated haemoglobin, body mass index, duration of diabetes, and age did not demonstrate statistically significant correlation with the facial erythema index. Study limitations: This is an observational study. Elevation of total antioxidant status could have been caused by several factors that might have also influenced the development of rubeosis faciei, including hyperbilirubinemia and hyperuricemia. Conclusions: The results contradicted expectations. Total antioxidant status correlated positively with facial erythema index; however, there was no correlation with oxidative stress and skin autofluorescence. Further investigations should be conducted to reveal the cause of total antioxidant status elevation in patients with rubeosis faciei.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent691445
dc.identifier.citationZavorins, A, Silova, A, Voicehovska, J & Kisis, J 2019, 'Rubeosis faciei diabeticorum is not associated with oxidative stress and skin autofluorescence', Anais Brasileiros de Dermatologia, vol. 94, no. 5, pp. 561-566. https://doi.org/10.1016/j.abd.2019.09.016
dc.identifier.doi10.1016/j.abd.2019.09.016
dc.identifier.issn0365-0596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/4141
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85076795402&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetic angiopathies
dc.subjectErythema
dc.subjectFace
dc.subjectGlycation end products, advanced
dc.subjectOxidative stress
dc.subjectSkin manifestations
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectDermatology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleRubeosis faciei diabeticorum is not associated with oxidative stress and skin autofluorescenceen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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