Clinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries : a randomised clinical trial

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dc.contributor.authorMaldupa, Ilze
dc.contributor.authorInnes, Nicola
dc.contributor.authorViduskalne, Ilona
dc.contributor.authorBrinkmane, Anda
dc.contributor.authorSenakola, Egita
dc.contributor.authorKrūmiņa, Karīna
dc.contributor.authorUribe, Sergio E
dc.contributor.institutionDepartment of Conservative Dentistry and Oral Health
dc.date.accessioned2024-04-16T07:30:01Z
dc.date.available2024-04-16T07:30:01Z
dc.date.issued2024-04-07
dc.descriptionPublisher Copyright: © The Author(s) 2024.
dc.description.abstractKnowledge gaps exist regarding optimal silver diammine fluoride (SDF) regimens and the efficacy of new products for arresting dental caries in young children. We evaluated the effectiveness of 38%-SDF (SDI-RivaStar), Tiefenfluorid (TF) comparing with Placebo (P), all in conjunction with behavioural modification (BM), in preventing major complications (endodontic/extractions/pain)-a patient-centred outcome-due to early childhood caries over 12 months in children under 71-months. A six-arm, patient/parent-blinded, superiority, placebo-controlled randomised control trial at the university clinic in Riga, Latvia, from 1/9/20-31/8/22 (Protocol registration ISRCTN17005348). The trial tested six protocols, using three compounds (P/SDF/TF) under two regimes: annual and biannual (P1/P2/TF1/TF2/SDF1/SDF2) for major complications. Secondary outcomes included minor complications and parental satisfaction. All groups received BM. 373/427 randomised children (87.3%) completed the study. SDF2 had a significantly lower rate and risk of major (21.5%, OR = 0.28, 95%CI [0.11, 0.72], p < 0.05) and minor complications (OR = 0.16 (95%CI [0.05, 0.50], p = 0.002). Overall satisfaction was 96% (p > 0.05). SDF biannual application with BM effectively prevented major complications of early childhood caries and was well accepted by children and their parents. Trial registration number: ISRCTN17005348, principal investigator: Ilze Maldupa, registration date: 30/06/2021.Clinical trial registration number: ISRCTN registry: ISRCTN17005348, https://doi.org/10.1186/ISRCTN17005348 , registration date: 30/06/2021.en
dc.description.statusPeer reviewed
dc.format.extent11
dc.format.extent3283506
dc.identifier.citationMaldupa, I, Innes, N, Viduskalne, I, Brinkmane, A, Senakola, E, Krūmiņa, K & Uribe, S E 2024, 'Clinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries : a randomised clinical trial', Scientific Reports, vol. 14, no. 1, 8123, pp. 1-11. https://doi.org/10.1038/s41598-024-58850-w
dc.identifier.doi10.1038/s41598-024-58850-w
dc.identifier.issn2045-2322
dc.identifier.otherPubMedCentral: PMC10998894
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15432
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85189312631&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHumans
dc.subjectChild, Preschool
dc.subjectCariostatic Agents/therapeutic use
dc.subjectFluoride Treatment
dc.subjectDental Caries/prevention & control
dc.subjectDental Caries Susceptibility
dc.subjectPatient Satisfaction
dc.subjectFluorides, Topical/therapeutic use
dc.subjectTreatment Outcome
dc.subjectSilver Compounds/therapeutic use
dc.subjectQuaternary Ammonium Compounds/therapeutic use
dc.subjectParents
dc.subjectPersonal Satisfaction
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleClinical effectiveness/child-patient and parent satisfaction of two topical fluoride treatments for caries : a randomised clinical trialen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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