Evaluation of Genetic Diversity and Virulence Potential of Legionella pneumophila Isolated from Water Supply Systems of Residential Buildings in Latvia

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dc.contributor.authorValciņa, Olga
dc.contributor.authorPūle, Daina
dc.contributor.authorĶibilds, Juris
dc.contributor.authorLabecka, Linda
dc.contributor.authorTerentjeva, Margarita
dc.contributor.authorKrūmiņa, Angelika
dc.contributor.authorBērziņš, Aivars
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2024-01-12T14:55:02Z
dc.date.available2024-01-12T14:55:02Z
dc.date.issued2023-07
dc.description.abstractLegionella is an opportunistic pathogen with a biphasic life cycle that occasionally infects humans. The aim of the study was to assess the distribution of virulence genes and genetic diversity among L. pneumophila isolated from water supply systems of residential buildings in Latvia. In total, 492 water samples from 200 residential buildings were collected. Identification of Legionella spp. was performed according to ISO 11731, and 58 isolates were subjected to whole-genome sequencing. At least one Legionella-positive sample was found in 112 out of 200 apartment buildings (56.0%). The study revealed extensive sequence-type diversity, where 58 L. pneumophila isolates fell into 36 different sequence types. A total of 420 virulence genes were identified, of which 260 genes were found in all sequenced L. pneumophila isolates. The virulence genes enhC, htpB, omp28, and mip were detected in all isolates, suggesting that adhesion, attachment, and entry into host cells are enabled for all isolates. The relative frequency of virulence genes among L. pneumophila isolates was high. The high prevalence, extensive genetic diversity, and the wide range of virulence genes indicated that the virulence potential of environmental Legionella is high, and proper risk management is of key importance to public health.en
dc.description.statusPeer reviewed
dc.format.extent1029159
dc.identifier.citationValciņa, O, Pūle, D, Ķibilds, J, Labecka, L, Terentjeva, M, Krūmiņa, A & Bērziņš, A 2023, 'Evaluation of Genetic Diversity and Virulence Potential of Legionella pneumophila Isolated from Water Supply Systems of Residential Buildings in Latvia', Pathogens, vol. 12, no. 7, 884. https://doi.org/10.3390/pathogens12070884
dc.identifier.doi10.3390/pathogens12070884
dc.identifier.issn2076-0817
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/15102
dc.identifier.urlhttps://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:001037624400001
dc.language.isoeng
dc.relation.ispartofPathogens
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLegionella
dc.subjectresidential buildings
dc.subjectvirulence factors
dc.subjectvirulence genes
dc.subjectsequence type
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEvaluation of Genetic Diversity and Virulence Potential of Legionella pneumophila Isolated from Water Supply Systems of Residential Buildings in Latviaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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