Non-Aziridination Approaches to 3-Arylaziridine-2-carboxylic Acid Derivatives and 3-Aryl-(aziridin-2-yl)ketones

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dc.contributor.authorStrumfs, Boriss
dc.contributor.authorVeļikijs, Kirils
dc.contributor.authorUljanovs, Romans
dc.contributor.authorSinkarevs, Stanislavs
dc.contributor.authorStrumfa, Ilze
dc.contributor.institutionDepartment of Pathology
dc.date.accessioned2022-10-06T13:20:01Z
dc.date.available2022-10-06T13:20:01Z
dc.date.issued2022-06-01
dc.descriptionFunding Information: APC was covered by Riga Stradins University, Riga, Latvia. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractHighly functionalized aziridines, including compounds with aromatic moieties, are attractive substrates both in synthetic and medical areas of chemistry. There is a broad and interesting set of synthetic methods for reaching these compounds. Aziridination represents the most explored tool, but there are several other more specific, less well-known, but highly promising approaches. Therefore, the current review focuses on recently described or updated ways to obtain 3-arylated aziridines via different non-aziridination-based synthetic methods, reported mainly since 2000. The presented methods belong to two main directions of synthesis, namely, cyclization of open-chain substrates and rearrangement of other heterocycles. Cyclization of open-chain substrates includes the classic Gabriel-Cromwell type cyclization of halogenated substrates with amines, base-promoted cyclization of activated aminoalcohols (or its analogues), and the oxidative cyclization of β-dicarbonyls. Rearrangements of other heterocycles are presented as the Baldwin rearrangement of 4-isoxazolines, the cycloaddition of 1.3-dipoles or dienes to 2H-azirines, and the addition of C-and N-nucleophiles to the double bond of azirines.en
dc.description.statusPeer reviewed
dc.format.extent20
dc.format.extent7664332
dc.identifier.citationStrumfs, B, Veļikijs, K, Uljanovs, R, Sinkarevs, S & Strumfa, I 2022, 'Non-Aziridination Approaches to 3-Arylaziridine-2-carboxylic Acid Derivatives and 3-Aryl-(aziridin-2-yl)ketones', International Journal of Molecular Sciences, vol. 23, no. 11, 5919. https://doi.org/10.3390/ijms23115919
dc.identifier.doi10.3390/ijms23115919
dc.identifier.issn1661-6596
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9643
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85130770377&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject4-isoxazolines
dc.subjectaziridines
dc.subjectazirines
dc.subjectBaldwin rearrangement
dc.subjectcyclization
dc.subjectcycloaddition
dc.subject1.4 Chemical sciences
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleNon-Aziridination Approaches to 3-Arylaziridine-2-carboxylic Acid Derivatives and 3-Aryl-(aziridin-2-yl)ketonesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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