Five days of bed rest in young and old adults : Retainment of skeletal muscle mass with neuromuscular electrical stimulation
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Date
2024-08
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Abstract
The consequences of short-term disuse are well known, but effective countermeasures remain elusive. This study investigated the effects of neuromuscular electrical stimulation (NMES) during 5 days of bed rest on retaining lower limb muscle mass and muscle function in healthy young and old participants. One leg received NMES of the quadriceps muscle (3 × 30min/day) (NMES), and the other served as a control (CON). Isometric quadriceps strength (MVC), rate of force development (RFD), lower limb lean mass, and muscle thickness were assessed pre-and post-intervention. Muscle thickness remained unaltered with NMES in young and increased in old following bed rest, while it decreased in CON legs. In old participants, mid-thigh lean mass (MTLM) was preserved with NMES while decreased in CON legs. In the young, only a tendency to change with bed rest was detected for MTLM. MVC and early-phase RFD decreased in young and old, irrespective of NMES. In contrast, late-phase RFD was retained in young participants with NMES, while it decreased in young CON legs, and in the old, irrespective of NMES. NMES during short-term bed rest preserved muscle thickness but not maximal muscle strength. While young and old adults demonstrated similar adaptive responses in preventing the loss of skeletal muscle thickness, RFD was retained in the young only.
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Publisher Copyright: © 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Keywords
aging, atrophy, disuse, muscle strength, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, Physiology, Physiology (medical)
Citation
Hansen, S K, Hansen, P, Nygaard, H, Grønbæk, H D, Berry, T W, Olsen, C M, Aagaard, P, Hvid, L G, Agergaard, J, Dela, F & Suetta, C 2024, 'Five days of bed rest in young and old adults : Retainment of skeletal muscle mass with neuromuscular electrical stimulation', Physiological Reports, vol. 12, no. 16, e16166. https://doi.org/10.14814/phy2.16166