Evaluation of axonal optic nerve damage using visual evoked potentials and optical coherence tomography in patients with multiple sclerosis

Simple item page
dc.contributor.authorPastare, Daina
dc.contributor.authorĶire, Ieva
dc.contributor.authorErts, Renars
dc.contributor.authorLaganovska, Guna
dc.contributor.authorMillers, Andrejs
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.contributor.institutionDepartment of Ophthalmology
dc.date.accessioned2021-04-22T08:05:01Z
dc.date.available2021-04-22T08:05:01Z
dc.date.issued2013
dc.description.abstractBackground and Objective: Axonal tissue impairment plays a substantial role in the development of disability in multiple sclerosis. The aim of our study was to analyze the clinical utility of visual evoked potentials (VEP) and optical coherence tomography (OCT) in the diagnosis of optic nerve axonal damage and to determine the correlation between the retinal nerve fiber layer at the temporal quadrant (RNFLT) thickness and the VEP amplitude in multiple sclerosis patients with and without a history of acute optic neuritis (ON). Material and Methods: This cross-sectional study included 69 relapsing-remitting patients with multiple sclerosis from Pauls Stradins Clinical University Hospital, who were divided into 2 groups: with and without a history of ON. The RNFLT thickness and the VEP amplitude were measured. Results: A total of 25 clinically affected eyes were studied. VEP showed a higher sensitivity (64%) than OCT (50%) in supporting a clinical diagnosis of ON. A significant correlation was found between the RNFLT thickness in the temporal segment and the average VEP amplitude both in the eyes of MS patients with (rs=0.42, P=0.01) and without a history of ON (rs=0.44, P<0.001). Conclusions: The evidence from this study suggests that diagnostics of optic nerve axonal damage is feasible by means of using the average VEP amplitude instead of OCT alone. However, the combination of VEP and OCT increases the chance to confirm the existence of ON. A significant correlation was found between structural and functional vision parameters for both patients with and without a history of ON.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent139356
dc.identifier.citationPastare, D, Ķire, I, Erts, R, Laganovska, G & Millers, A 2013, 'Evaluation of axonal optic nerve damage using visual evoked potentials and optical coherence tomography in patients with multiple sclerosis', Medicina (Lithuania), vol. 49, no. 11, pp. 474-478. https://doi.org/10.3390/medicina49110074
dc.identifier.doi10.3390/medicina49110074
dc.identifier.issn1010-660X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3892
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84901609314&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAxonal damage
dc.subjectMultiple sclerosis
dc.subjectOptic nerve
dc.subjectOptical coherence tomography
dc.subjectVisual evoked potentials
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleEvaluation of axonal optic nerve damage using visual evoked potentials and optical coherence tomography in patients with multiple sclerosisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Evaluation_of_Axonal_Optic_Nerve_Damage_Using_Visual_Evoked.pdf
Size:
136.09 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure