Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms

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dc.contributor.authorSimtniece, Zane
dc.contributor.authorVanags, Andrejs
dc.contributor.authorStrumfa, Ilze
dc.contributor.authorSperga, Maris
dc.contributor.authorVasko, Ervins
dc.contributor.authorPrieditis, Peteris
dc.contributor.authorTrapencieris, Peteris
dc.contributor.authorGardovskis, Janis
dc.contributor.institutionDepartment of Pathology
dc.contributor.institutionDepartment of Surgery
dc.contributor.institutionDepartment of Radiology
dc.date.accessioned2021-08-12T07:40:01Z
dc.date.available2021-08-12T07:40:01Z
dc.date.issued2015-07-30
dc.descriptionPublisher Copyright: © 2015, Versalius University Medical Publisher. All rights reserved.
dc.description.abstractThe study represents a comprehensive retrospective morphological and immunohistochemical profiling of pancreatic neuroendocrine neoplasms (PNENs) in order to reveal the associations between morphological and molecular parameters. The local tumour spread (T), presence of metastases in regional lymph nodes (N) and distant organs (M), tumour grade (G) and resection line status (R) by pathology findings (pTNMGR), mitotic activity, perineural, vascular and lymphatic invasion were assessed in 16 surgically resected PNENs. By immunohistochemistry, expression of Ki-67, p53, p27, p21, cyclin D1, Bcl-2, E-cadherin, CD44, vimentin, cyclooxygenase 2 (COX-2), microvascular density, and cytokeratin (CK) spectrum, along with neuroendocrine, intestinal and squamous markers were detected. Descriptive statistics, Chi-square test, Spearman’s rank correlation, Mann–Whitney and Kruskal–Wallis methods were applied; p < 0.05 was considered significant. Ki-67, CK19, p63, vimentin and COX-2 were significantly up-regulated in PNENs in comparison to benign pancreatic islets. A complex network of morphological and molecular associations was identified. Ki-67 correlated with PNEN size (p = 0.022), the World Health Organization 2004 and 2010 classification grades (p = 0.021 and p = 0.002), stage (p = 0.028) and mitotic count (p = 0.007) but among molecular markers – with CK19 (p = 0.033) and vimentin (p = 0.045). CK19 was significantly up-regulated in PNENs, having higher pT (p = 0.018), pR (p = 0.025), vascular (p = 0.020), perineural (p = 0.026) and lymphatic invasion (p = 0.043). In conclusion, proliferation activity (by Ki-67), E-cadherin, vimentin and CK19 are important molecular characteristics of PNENs due to significant associations with morphological tumour characteristics, pTNMGR and invasive growth.en
dc.description.statusPeer reviewed
dc.format.extent19
dc.format.extent810683
dc.identifier.citationSimtniece, Z, Vanags, A, Strumfa, I, Sperga, M, Vasko, E, Prieditis, P, Trapencieris, P & Gardovskis, J 2015, 'Morphological and immunohistochemical profile of pancreatic neuroendocrine neoplasms', Polish Journal of Pathology, vol. 66, no. 2, pp. 176-194. https://doi.org/10.5114/pjp.2015.53015
dc.identifier.doi10.5114/pjp.2015.53015
dc.identifier.issn1233-9687
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5983
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84938088136&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPolish Journal of Pathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytokeratin 19
dc.subjectE-cadherin
dc.subjectImmunohistochemistry
dc.subjectPancreatic neuroendocrine neoplasm
dc.subjectVimentin
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPathology and Forensic Medicine
dc.titleMorphological and immunohistochemical profile of pancreatic neuroendocrine neoplasmsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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