Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection

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dc.contributor.authorIsaguliants, Maria
dc.contributor.authorKrasnyak, Stepan
dc.contributor.authorSmirnova, Olga
dc.contributor.authorColonna, Vincenza
dc.contributor.authorApolikhin, Oleg
dc.contributor.authorBuonaguro, Franco M.
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2022-01-26T13:10:01Z
dc.date.available2022-01-26T13:10:01Z
dc.date.issued2021-12
dc.descriptionFunding Information: RFBR grant 17–54-30002, Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075–15–2019-1660) to Olga Smirnova. Publisher Copyright: © 2021, The Author(s).
dc.description.abstractHuman papillomavirus (HPV) is a sexually transmitted infection common among men and women of reproductive age worldwide. HPV viruses are associated with epithelial lesions and cancers. HPV infections have been shown to be significantly associated with many adverse effects in reproductive function. Infection with HPVs, specifically of high-oncogenic risk types (HR HPVs), affects different stages of human reproduction, resulting in a series of adverse outcomes: 1) reduction of male fertility (male infertility), characterized by qualitative and quantitative semen alterations; 2) impairment of couple fertility with increase of blastocyst apoptosis and reduction of endometrial implantation of trophoblastic cells; 3) defects of embryos and fetal development, with increase of spontaneous abortion and spontaneous preterm birth. The actual molecular mechanism(s) by which HPV infection is involved remain unclear. HPV-associated infertility as Janus, has two faces: one reflecting anti-HPV immunity, and the other, direct pathogenic effects of HPVs, specifically, of HR HPVs on the infected/HPV-replicating cells. Adverse effects observed for HR HPVs differ depending on the genotype of infecting virus, reflecting differential response of the host immune system as well as functional differences between HPVs and their individual proteins/antigens, including their ability to induce genetic instability/DNA damage. Review summarizes HPV involvement in all reproductive stages, evaluate the adverse role(s) played by HPVs, and identifies mechanisms of viral pathogenicity, common as well as specific for each stage of the reproduction process.en
dc.description.statusPeer reviewed
dc.format.extent1337264
dc.identifier.citationIsaguliants, M, Krasnyak, S, Smirnova, O, Colonna, V, Apolikhin, O & Buonaguro, F M 2021, 'Genetic instability and anti-HPV immune response as drivers of infertility associated with HPV infection', Infectious Agents and Cancer, vol. 16, no. 1, 29. https://doi.org/10.1186/s13027-021-00368-1
dc.identifier.doi10.1186/s13027-021-00368-1
dc.identifier.issn1750-9378
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/7299
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85105558930&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInfectious Agents and Cancer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDNA damage
dc.subjectGastrulation
dc.subjectGenomic instability
dc.subjectHuman papilloma viruses of high oncogenic risk type
dc.subjectInfertility
dc.subjectOocyte
dc.subjectReproductive health
dc.subjectSperm cells
dc.subjectSpontaneous abortion
dc.subjectViral integration
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectEpidemiology
dc.subjectOncology
dc.subjectCancer Research
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGenetic instability and anti-HPV immune response as drivers of infertility associated with HPV infectionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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