Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region

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dc.contributor.authorKornevs, Egils
dc.contributor.authorApse, Ingus Arnolds
dc.contributor.authorSafronovs, Toms Janis
dc.contributor.authorKrastiņa, Aija
dc.contributor.authorPaparde, Arturs
dc.contributor.authorLauskis, Gunars
dc.contributor.authorSalms, Girts
dc.contributor.institutionDepartment of Oral and Maxillofacial Surgery and Oral Medicine
dc.contributor.institutionRīga Stradiņš University
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2021-09-08T09:15:01Z
dc.date.available2021-09-08T09:15:01Z
dc.date.issued2020
dc.descriptionCopyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
dc.description.abstractBACKGROUND AND OBJECTIVES: To test if there are different outcomes in basal cell carcinoma for lesion size, histopathology, localization, and recurrence rates. MATERIALS AND METHODS: A total of 395 patients with BCC localized in the neck, nose and ear regions who were surgically treated in Latvian Oncology Centre between 2006-2011 were analyzed retrospectively. The data were analyzed using modified classification based on Clarks et al. (2014) and McKenzie et al. (2016). RESULTS: Three hundred and ninety-five cases of BCC that were surgically treated in head and neck region were reviewed. Results were tabulated in four categories: anatomical region, histopathology, lesion size, and recurrence rates. Classification by anatomical region: 228 cases in the nose region, 82 cases in the neck region, 82 cases in the ear region. Classification by histopathology: 259 cases presented as low risk BCC [nodular, pigmented, adenoid, keratotic and cystic], 21 cases presented as superficial, 94 cases presented as mixed, and 21 cases presented as high-risk BCC (metatypical, morphea form). Mann-Whitney U test was used to compare recurrent BCC cases to non-recurrent cases. Significantly higher recurrence rates were observed if BCC at the time of the excision was ≥10 mm (p<0.001). Significance was also noted in cases where histopathology was mixed BCC and in cases where mixed BCC was localized to the nose region (p<0.001). CONCLUSION: More attention should be brought to assessing classification and clinical treatment synergy. Higher recurrence rates are observed when lesions occur in high risk anatomical region (H zone), when lesion size reaches or exceeds 20 mm in diameter, and when lesion is subtyped as mixed BCC. It is crucial to evaluate risk factors such as BCC subtype and localization, as these are associated with a higher rate of recurrence when present in a single lesion. These risk factors, together with pre-treatment lesion evaluation will enable formulation of better treatment plan and prognostic aspects in each case.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.format.extent388019
dc.identifier.citationKornevs, E, Apse, I A, Safronovs, T J, Krastiņa, A, Paparde, A, Lauskis, G & Salms, G 2020, 'Basal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose region', Stomatologija, vol. 22, no. 1, pp. 9-16. < https://sbdmj.lsmuni.lt/201/201-02.pdf >
dc.identifier.issn1392-8589
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6242
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85088675299&partnerID=8YFLogxK
dc.identifier.urlhttps://sbdmj.lsmuni.lt/201/201-02.pdf
dc.language.isoeng
dc.relation.ispartofStomatologija
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbasal cell carcinoma
dc.subjectrecurrence
dc.subjecthead and neck oncology
dc.subjectnon-melanoma skin cancer
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBasal Cell Carcinoma. Analysis of 395 cases localized in the neck, ear and nose regionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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