Dietary polyphenols targeting arterial stiffness : Interplay of contributing mechanisms and gut microbiome-related metabolism

Simple item page
dc.contributor.authorDe Bruyne, Tess
dc.contributor.authorSteenput, Bieke
dc.contributor.authorRoth, Lynn
dc.contributor.authorDe Meyer, Guido R.Y.
dc.contributor.authorDos Santos, Claudia Nunes
dc.contributor.authorValentová, Kateřina
dc.contributor.authorDambrova, Maija
dc.contributor.authorHermans, Nina
dc.date.accessioned2021-04-09T12:35:03Z
dc.date.available2021-04-09T12:35:03Z
dc.date.issued2019-03
dc.descriptionPublisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractIncreased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness.en
dc.description.statusPeer reviewed
dc.format.extent2186926
dc.identifier.citationDe Bruyne, T, Steenput, B, Roth, L, De Meyer, G R Y, Dos Santos, C N, Valentová, K, Dambrova, M & Hermans, N 2019, 'Dietary polyphenols targeting arterial stiffness : Interplay of contributing mechanisms and gut microbiome-related metabolism', Nutrients, vol. 11, no. 3, 578. https://doi.org/10.3390/nu11030578
dc.identifier.doi10.3390/nu11030578
dc.identifier.issn2072-6643
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3728
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85062854208&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofNutrients
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAging
dc.subjectAnti-inflammatory
dc.subjectAntioxidant
dc.subjectArterial stiffness
dc.subjectAutophagy
dc.subjectGut microbiome
dc.subjectPolyphenol biotransformation
dc.subjectPolyphenols
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectFood Science
dc.subjectNutrition and Dietetics
dc.titleDietary polyphenols targeting arterial stiffness : Interplay of contributing mechanisms and gut microbiome-related metabolismen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Dietary_Polyphenols_Targeting_Arterial_Stiffness.pdf
Size:
2.09 MB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure