EXPLORING INTESTINAL PERMEABILITY : CONCEPT, DIAGNOSIS, CONNECTION TO BOWEL DISEASE, AND IRON DEFICIENCY

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dc.contributor.authorBasina, Olesja
dc.contributor.authorDerovs, Aleksejs
dc.contributor.authorDerova, Jelena
dc.contributor.authorLejniece, Sandra
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionDepartment of Infectology
dc.date.accessioned2024-09-24T07:45:01Z
dc.date.available2024-09-24T07:45:01Z
dc.date.issued2024-08
dc.descriptionPublisher Copyright: © The Authors.
dc.description.abstractOver the recent years, intestinal permeability has become a major feature of gut health. The objective of this paper is to present a literature-based overview of the current understanding on intestinal permeability. The concept of intestinal permeability started its development from the discovery of tight junctions — protein complexes that are separated between the epithelial cells. Histopathology is the main option of microscopic diagnosis, which allows to determine changes that occur in the tight junction, inflammation, and damaged epithelial cells. Additionally, intestinal fatty acid-binding protein I-FABP and zonulin are suggested as biomarkers of epithelial barrier abruption. As for visual detection, literature proposes capsule endoscopy and confocal laser endomicroscopy. Using the latter it is possible to produce images of small intestinal morphology and visualise the small intestinal luminal elements, cells, villi as well as crypts. However, advancements in digital capsule endoscopy are more applicable and aid in research of intestinal permeability and enteropathy, also giving promising results in treatment. Although damage to intestinal permeability can be classified as a certain enteropathy and then the association of some enteropathies with iron deficiency already has been established, direct association of iron deficiency and intestinal permeability is yet to be explored.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent103205
dc.identifier.citationBasina, O, Derovs, A, Derova, J & Lejniece, S 2024, 'EXPLORING INTESTINAL PERMEABILITY : CONCEPT, DIAGNOSIS, CONNECTION TO BOWEL DISEASE, AND IRON DEFICIENCY', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 78, no. 4, pp. 244-248. https://doi.org/10.2478/prolas-2024-0034
dc.identifier.doi10.2478/prolas-2024-0034
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/16705
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85204078879&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbowel disease
dc.subjectendoscopy
dc.subjectenteropathy
dc.subjectintestine
dc.subjectiron deficiency anaemia
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleEXPLORING INTESTINAL PERMEABILITY : CONCEPT, DIAGNOSIS, CONNECTION TO BOWEL DISEASE, AND IRON DEFICIENCYen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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