Saistība starp zema blīvuma lipoproteīnu holesterīna līmeni un Covid-19 slimības smagumu un iznākumu.
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Date
2023
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Kopš 2020. gada pasaule dzīvo COVID-19 pandēmijas apstākļos. Pašlaik pasaulē ir reģistrēti vairāk kā 600 miljoni COVID-19 infekcijas gadījumu, pēc PVO 2022. gada decembra datiem nomira vairāk kā 6,5 miljonu cilvēku [1]. Bet neskatoties uz globālu pandēmiju, cilvēkiem ir blakusslimības, piemēram, koronārā sirds slimība, kas Latvijā joprojām ir viens no biežākajiem nāves cēloņiem [2], [3]. Ir zināms, ka zema blīvuma lipoproteīnu holesterīna līmenis ir viens no koronārās sirds slimības riska faktoriem, bet nav zināms, kā tas ietekmē uz COVID-19 slimības gaitu, smagumu un iznākumu . Šobrīd Latvijā ir nav pietiekami daudz datu par šī darba tēmu.
Šī retrospektīva pētījuma mērķis bija noskaidrot saistību starp zema blīvuma lipoproteīnu holesterīna līmeni un Covid-19 slimības smagumu un iznākumu. Latvijas slimnīcās arhīvos tika analizētas COVID-19 pozitīvo pacientu slimības vēstures ar laboratoriski noteiktu zema blīvuma lipoproteīnu holesterīnu.
Pētījuma laikā netika atrasta korelācija starp zema blīvuma lipoproteīnu holesterīna līmeni un COVOD-19 slimības smagumu un iznākumu. Tomēr izdevās pierādīt, ka pacientiem ar lieko ķermeņa svaru, paaugstinātu triglicerīdu līmeni bija smagāka COVID-19 slimības gaita. Analizējot COVID-19 slimības smagumu ar laboratoriskiem rādītājiem, tika konstatēta pozitīva korelācijas starp COVID-19 slimības smaguma pakāpi un D – dimēriem, fibrinogēnu, ALAT un CRO.
From 2020 the world is living under the conditions of COVID-19 pandemic. Currently, more than 600 million cases of COVID-19 infection have been registered in the world, according to WHO data from December 2022, more than 6.5 million people died [1]. But despite the global pandemic, people have co-morbidities, such as coronary heart disease, which is still one of the most common causes of death in Latvia [2], [3]. Low-density lipoprotein cholesterol is known to be one of the risk factors for coronary heart disease, but how this affects the course, severity, and outcome of COVID-19 is unknown. Currently, there is not enough data on the topic of this work in Latvia. The main purpose of this retrospective study was to find a relationship between low-density lipoprotein cholesterol and the severity and outcome of COVID-19 disease. The medical histories of COVID-19 positive patients with laboratory-determined low-density lipoprotein cholesterol levels were analyzed in Latvian hospital archives. The results of the study show that low-density lipoprotein cholesterol levels were not associated with disease severity and outcome of COVID-19. At the same time, it was found that in patients with overweight, elevated triglyceride levels, the course of COVID-19 disease was more severe. Analyzing the severity of the disease of COVID-19 with laboratory indicators, positive correlations were found between the severity of the disease of COVID-19 and D-dimers, fibrinogen, ALAT and CRP.
From 2020 the world is living under the conditions of COVID-19 pandemic. Currently, more than 600 million cases of COVID-19 infection have been registered in the world, according to WHO data from December 2022, more than 6.5 million people died [1]. But despite the global pandemic, people have co-morbidities, such as coronary heart disease, which is still one of the most common causes of death in Latvia [2], [3]. Low-density lipoprotein cholesterol is known to be one of the risk factors for coronary heart disease, but how this affects the course, severity, and outcome of COVID-19 is unknown. Currently, there is not enough data on the topic of this work in Latvia. The main purpose of this retrospective study was to find a relationship between low-density lipoprotein cholesterol and the severity and outcome of COVID-19 disease. The medical histories of COVID-19 positive patients with laboratory-determined low-density lipoprotein cholesterol levels were analyzed in Latvian hospital archives. The results of the study show that low-density lipoprotein cholesterol levels were not associated with disease severity and outcome of COVID-19. At the same time, it was found that in patients with overweight, elevated triglyceride levels, the course of COVID-19 disease was more severe. Analyzing the severity of the disease of COVID-19 with laboratory indicators, positive correlations were found between the severity of the disease of COVID-19 and D-dimers, fibrinogen, ALAT and CRP.
Description
Klīniskā farmācija
Clinical Pharmacy
Veselības aprūpe
Health Care
Clinical Pharmacy
Veselības aprūpe
Health Care
Keywords
COVID-19 infekcija, koronārā sirds slimība, dislipidēmija, zema blīvuma lipoproteīna holesterīns, retrospektīvs pētījums, COVID-19 infection, coronary heart disease, dyslipidaemia, low-density lipoprotein cholesterol, retrospective study