The effect of intranasally administered tlr3 agonist larifan on metabolic profile of microglial cells in rat with c6 glioma

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dc.contributor.authorHurmach, Y.
dc.contributor.authorRudyk, M.
dc.contributor.authorSvyatetska, V.
dc.contributor.authorSenchylo, N.
dc.contributor.authorSkachkova, O.
dc.contributor.authorPjanova, D.
dc.contributor.authorVaivode, K.
dc.contributor.authorSkivka, L.
dc.date.accessioned2023-08-29T13:30:01Z
dc.date.available2023-08-29T13:30:01Z
dc.date.issued2018
dc.descriptionPublisher Copyright: © 2018 Hurmach Y. et al.
dc.description.abstractGlioma-associated microglia/macrophages (Gam) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profile in rats with C6 glioma. Our results demonstrate progressive generation microglial cell population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain. Intranasally delivered TLR3 agonist is capable to abrogate the creation of this pro-tumoral immune infiltrates, probably, through the effect on myeloid-derived suppressor cells, and can be considered as a promising agent for glioma therapy aimed the Gam re-education.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent992557
dc.identifier.citationHurmach, Y, Rudyk, M, Svyatetska, V, Senchylo, N, Skachkova, O, Pjanova, D, Vaivode, K & Skivka, L 2018, 'The effect of intranasally administered tlr3 agonist larifan on metabolic profile of microglial cells in rat with c6 glioma', Ukrainian Biochemical Journal, vol. 90, no. 6, pp. 110-119. https://doi.org/10.15407/ubj90.06.110
dc.identifier.doi10.15407/ubj90.06.110
dc.identifier.issn2409-4943
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/14863
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85057317378&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofUkrainian Biochemical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlioma
dc.subjectImmunotherapy
dc.subjectMicroglia
dc.subjectToll-like receptor agonist
dc.subject1.6 Biological sciences
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectBiochemistry
dc.titleThe effect of intranasally administered tlr3 agonist larifan on metabolic profile of microglial cells in rat with c6 gliomaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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