HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling

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dc.contributor.authorKozlowska, Lucyna
dc.contributor.authorViegas, Susana
dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorDuca, Radu C.
dc.contributor.authorGodderis, Lode
dc.contributor.authorMartins, Carla
dc.contributor.authorCiura, Krzesimir
dc.contributor.authorJagiello, Karolina
dc.contributor.authorJoão Silva, Maria
dc.contributor.authorMahiout, Selma
dc.contributor.authorMārtiņsone, Inese
dc.contributor.authorMatisāne, Linda
dc.contributor.authorNieuwenhuyse, An van
dc.contributor.authorPuzyn, Tomasz
dc.contributor.authorSijko-Szpanska, Monika
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorSantonen, Tiina
dc.contributor.authorthe HBM4EU E-waste Study Team
dc.contributor.institutionInstitute of Occupational Safety and Environmental Health
dc.date.accessioned2025-01-27T09:25:01Z
dc.date.available2025-01-27T09:25:01Z
dc.date.issued2025-02
dc.descriptionPublisher Copyright: © 2025 The Author(s)
dc.description.abstractE-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing workers to explore metabolic changes associated with chemical exposures in e-waste recycling in Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data and urine samples were obtained from workers involved in the processing of e-waste (sorting, dismantling, shredding, pre-processing, metal, and non-metal processing), as well as from controls with no known occupational exposure. Pre- and post-shift urine samples were collected and analysed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS). A total of 32 endogenous urinary metabolites were annotated with a Variable Importance in Projection (VIP) above 2, indicating that e-waste recycling is mainly associated with changes in steroid hormone and neurotransmitter metabolism, energy metabolism, bile acid biosynthesis, and inflammation. The highest VIP was observed for dopamine-o-quinone, which is linked to Parkinson's disease. These and other changes in metabolism in workers employed in the processing of e-waste need further verification in targeted studies.en
dc.description.statusPeer reviewed
dc.format.extent12
dc.format.extent8788819
dc.identifier.citationKozlowska, L, Viegas, S, Scheepers, P T J, Duca, R C, Godderis, L, Martins, C, Ciura, K, Jagiello, K, João Silva, M, Mahiout, S, Mārtiņsone, I, Matisāne, L, Nieuwenhuyse, A V, Puzyn, T, Sijko-Szpanska, M, Verdonck, J, Santonen, T & the HBM4EU E-waste Study Team 2025, 'HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling', Environment International, vol. 196, 109281. https://doi.org/10.1016/j.envint.2025.109281
dc.identifier.doi10.1016/j.envint.2025.109281
dc.identifier.issn0160-4120
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/17038
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85215410622&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofEnvironment International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomarkers
dc.subjectMixture exposure
dc.subjectOccupational exposure
dc.subjectRecycling
dc.subjectUrine metabolomics
dc.subject3.3 Health sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Environmental Science
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 12 - Responsible Consumption and Production
dc.titleHBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recyclingen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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