Role of the Microbiome in the Pathogenesis and Treatment Perspectives of Atopic Dermatitis
No Thumbnail Available
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Atopiskais dermatīts ir viena no visbiežāk sastopamajām hroniskajām dermatoloģiskajām slimībām zīdaiņiem un bērniem. Jaunākie pētījumi liecina, ka mikrobioma pārmaiņas un AD var būt saistīts un ka iespējams pozitīvus rezultātus var sasniegt ar mikrobioma terapijas pieejām. Literatūras pārskata mērķis ir aplūkot mikrobioma pārmaiņu lomu AD patoģenēzē, un izpētīt uz mikrobiomu balstītas ārstēšanas pieejas AD gadījumā.
Secinājums: Mikrobiomam ir nozīmīga loma ādas slimību patoģenēzē.
Specifiski mikroorganismi ir saistīti ar atopiskā dermatīta patoģenozi, īpaši: Samazināts baktērijas Lactobacillus daudzums zarnās, Staphylococcus aureus baktērijas paaugstināts līmenis uz ādas.
Atopiskā dermatīta ārstēšanas iespējas, kuru pamatā ir mikrobioms, ir: Zarnu mikrobioma korekcija, lietojot probiotikas, ādas mikrobioma korekcija ar mikrobu transplantāciju.
Tomēr ir vajadzīgi turpmāki placebo kontrolēti pētījumi.
Atopic Dermatitis (AD) is one of the most common chronic dermatological diseases of infants and children. Recent studies show that a disbalance of the microbiome and AD can be associated and that positive results can be reached by microbiome-based treatment approaches. The aim of the current literature review is to provide an overview on studies that analyse the connections of gut microbiome dysfunction as well as skin microbiome dysfunction in the pathogenesis of Atopic Dermatitis. Further the literature review investigates microbiome-based treatment approaches in case of Atopic Dermatitis. Conclusion: The microbiome plays a significant role in the pathogenesis of skin diseases. Specific microorganisms are associated with the pathogenesis of Atopic Dermatitis, especially: The reduced abundance of the bacterium Lactobacillus in the gut, the elevated level of the bacterium Staphylococcus aureus on the skin. Microbiome-based treatment options of Atopic Dermatitis are: The regeneration of the dysbalanced gut microbiome by the administration of probiotics, the regeneration of the dysbalanced skin microbiome by microbial transplantation. More placebo-controlled studies are needed in the future.
Atopic Dermatitis (AD) is one of the most common chronic dermatological diseases of infants and children. Recent studies show that a disbalance of the microbiome and AD can be associated and that positive results can be reached by microbiome-based treatment approaches. The aim of the current literature review is to provide an overview on studies that analyse the connections of gut microbiome dysfunction as well as skin microbiome dysfunction in the pathogenesis of Atopic Dermatitis. Further the literature review investigates microbiome-based treatment approaches in case of Atopic Dermatitis. Conclusion: The microbiome plays a significant role in the pathogenesis of skin diseases. Specific microorganisms are associated with the pathogenesis of Atopic Dermatitis, especially: The reduced abundance of the bacterium Lactobacillus in the gut, the elevated level of the bacterium Staphylococcus aureus on the skin. Microbiome-based treatment options of Atopic Dermatitis are: The regeneration of the dysbalanced gut microbiome by the administration of probiotics, the regeneration of the dysbalanced skin microbiome by microbial transplantation. More placebo-controlled studies are needed in the future.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Atopiskais dermatīts, neirodermīts, mikrobioms, mikrobiota, zarnu mikrobioms, ādas mikrobioms, probiotiķi, mikrobioma transplantācija, Atopic Dermatitis, Neurodermitis, microbiome, microbiota, gut microbiome, skin microbiome, probiotics, microbial transplantation