Selected strategies to fight pathogenic bacteria

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dc.contributor.authorPlotniece, Aiva
dc.contributor.authorSobolev, Arkadij
dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorCarta, Fabrizio
dc.contributor.authorBjörkling, Fredrik
dc.contributor.authorFranzyk, Henrik
dc.contributor.authorYli-Kauhaluoma, Jari
dc.contributor.authorAugustyns, Koen
dc.contributor.authorCos, Paul
dc.contributor.authorDe Vooght, Linda
dc.contributor.authorGovaerts, Matthias
dc.contributor.authorAizawa, Juliana
dc.contributor.authorTammela, Päivi
dc.contributor.authorŽalubovskis, Raivis
dc.contributor.institutionDepartment of Pharmaceutical Chemistry
dc.date.accessioned2023-02-03T10:10:01Z
dc.date.available2023-02-03T10:10:01Z
dc.date.issued2023-01-11
dc.descriptionFunding Information: This review was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 951883 within SPRINGBOARD project. Publisher Copyright: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
dc.description.abstractNatural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.en
dc.description.statusPeer reviewed
dc.format.extent1
dc.format.extent4501524
dc.identifier.citationPlotniece, A, Sobolev, A, Supuran, C T, Carta, F, Björkling, F, Franzyk, H, Yli-Kauhaluoma, J, Augustyns, K, Cos, P, De Vooght, L, Govaerts, M, Aizawa, J, Tammela, P & Žalubovskis, R 2023, 'Selected strategies to fight pathogenic bacteria', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 38, no. 1, 2155816. https://doi.org/10.1080/14756366.2022.2155816
dc.identifier.doi10.1080/14756366.2022.2155816
dc.identifier.issn1475-6366
dc.identifier.otherunpaywall: 10.1080/14756366.2022.2155816
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/10270
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85146193051&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobials
dc.subjectbiofilms
dc.subjectbiopharmaceuticals
dc.subjectmetalloenzymes
dc.subjectnatural products
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.titleSelected strategies to fight pathogenic bacteriaen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/systematicreview

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