The association between serum lipids and risk of premature mortality in Latin America : A systematic review of population-based prospective cohort studies
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Date
2019
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Abstract
Objective. To synthetize the scientific evidence on the association between serum lipids and premature mortality in Latin America (LA). Methods. Five data bases were searched from inception without language restrictions: Embase, Medline, Global Health, Scopus and LILACS. Population-based studies following random sampling methods were identified. The exposure variable was lipid biomarkers (e.g., total, LDL- or HDL- cholesterol). The outcome was all-cause and cause-specific mortality. The risk of bias was assessed following the Newcastle-Ottawa criteria. Results were summarized qualitatively. Results. The initial search resulted in 264 abstracts, five (N = 27,903) were included for the synthesis. Three papers reported on the same study from Puerto Rico (baseline in 1965), one was from Brazil (1996) and one from Peru (2007). All reports analysed different exposure variables and used different risk estimates (relative risks, hazard ratios or odds ratios). None of the reviewed reports showed strong association between individual lipid biomarkers and all-cause or cardiovascular mortality. Conclusion. The available evidence is outdated, inconsistently reported on several lipid biomarker definitions and used different methods to study the long-term mortality risk. These findings strongly support the need to better ascertain the mortality risk associated with lipid biomarkers in LA.
Description
Funding Information: This work was supported by the Strategic Award, Wellcome Trust-Imperial College Centre for Global Health Research (100693/Z/12/Z), Imperial College London Wellcome Trust Institutional Strategic Support Fund [Global Health Clinical Research Training Fellowship] (294834/Z/16/Z ISSF ICL), and Rodrigo M Carrillo-Larco is supported by a Wellcome Trust International Training Fellowship (214185/Z/18/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: The following grant information was disclosed by the authors: Strategic Award, Wellcome Trust-Imperial College Centre for Global Health Research: 100693/Z/12/Z. Imperial College London Wellcome Trust Institutional Strategic Support Fund: 294834/Z/16/Z ISSF ICL. Wellcome Trust International Training Fellowship: 214185/Z/18/Z. Publisher Copyright: Copyright 2019 Carrillo-Larco et al.
Keywords
Cholesterol, Dyslipidaemias, Latin america, Survival, 3.1 Basic medicine, 1.1. Scientific article indexed in Web of Science and/or Scopus database, General Neuroscience, General Biochemistry,Genetics and Molecular Biology, General Agricultural and Biological Sciences, SDG 3 - Good Health and Well-being
Citation
Carrillo-Larco, R M, Albitres-Flores, L, Barengo, N C & Bernabe-Ortiz, A 2019, 'The association between serum lipids and risk of premature mortality in Latin America : A systematic review of population-based prospective cohort studies', PeerJ, vol. 2019, no. 10, e7856. https://doi.org/10.7717/peerj.7856