Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages

Simple item page
dc.contributor.authorLundqvist, Annika
dc.contributor.authorMagnusson, Lisa U.
dc.contributor.authorUllström, Christina
dc.contributor.authorKrasilnikova, Jelena
dc.contributor.authorTelysheva, Galina
dc.contributor.authorDizhbite, Tatjana
dc.contributor.authorHultén, Lillemor Mattsson
dc.contributor.institutionRīga Stradiņš University
dc.date.accessioned2021-07-05T10:30:01Z
dc.date.available2021-07-05T10:30:01Z
dc.date.issued2015-03-13
dc.descriptionFunding Information: This work was supported by the Swedish Research Council ( 521-2013-3588 ), the Swedish Heart-Lung Foundation ( 20130231 ), and Laboratory Medicine, Sahlgrenska University Hospital , Gothenburg Sweden. Publisher Copyright: © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
dc.description.abstractInflammation in the vascular wall is important for the development of atherosclerosis. We have previously shown that inflammatory macrophages are more abundant in human atherosclerotic lesions than in healthy arteries. Activated macrophages produce reactive oxygen species (ROS) that promote local inflammation in atherosclerotic lesions. Here, we investigated the role of oregonin, a diarylheptanoid, on proinflammatory responses in primary human macrophages and found that oregonin decreased cellular lipid accumulation and proinflammatory cytokine secretion. We also found that oregonin decreased ROS production in macrophages. Additionally, we observed that treatment of lipopolysaccharide-exposed macrophages with oregonin significantly induced the expression of antioxidant-related genes, including Heme oxygenase-1 and NADPH dehydrogenase quinone 1. In summary, we have shown that oregonin reduces lipid accumulation, inflammation and ROS production in primary human macrophages, indicating that oregonin has anti-inflammatory bioactivities.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.format.extent774292
dc.identifier.citationLundqvist, A, Magnusson, L U, Ullström, C, Krasilnikova, J, Telysheva, G, Dizhbite, T & Hultén, L M 2015, 'Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages', Biochemical and Biophysical Research Communications, vol. 458, no. 3, pp. 693-699. https://doi.org/10.1016/j.bbrc.2015.01.161
dc.identifier.doi10.1016/j.bbrc.2015.01.161
dc.identifier.issn0006-291X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5828
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84924080685&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-inflammatory
dc.subjectCytokines
dc.subjectLipid accumulation
dc.subjectMacrophages
dc.subjectOregonin
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectBiophysics
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectCell Biology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleOregonin reduces lipid accumulation and proinflammatory responses in primary human macrophagesen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Oregonin_reduces_lipid_accumulation.pdf
Size:
756.14 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure