Characterization of Pro- and Anti-Inflammatory Tissue Factors in Rosacea : A Pilot study

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dc.contributor.authorLohova, Elizabeta
dc.contributor.authorPilmane, Mara
dc.contributor.authorRone-Kupfere, Mara
dc.contributor.authorKisis, Janis
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-09-06T12:10:01Z
dc.date.available2021-09-06T12:10:01Z
dc.date.issued2020-12
dc.descriptionPublisher Copyright: © 2020, MDPI AG. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
dc.description.abstractRosacea is a chronic inflammatory skin disease mainly affecting the facial skin. Our aim was to determine the appearance of pro- and anti- inflammatory cytokines in rosacea-affected facial tissue. Materials and Methods: Rosacea tissue were obtained from eight patients (aged 35 to 50 years). The control group (CG) included four facial skin samples (49 to 70 years). Routine staining and immunohistochemistry for IL-1, IL-10, LL-37, HBD-2, and HBD-4 proceeded. Results: Inflammation was observed in all the rosacea samples. A statistically significant difference was seen between epithelial HBD-2 positive cells in comparison to the control. There was a strong positive correlation between HBD-4 in the epithelium and HBD-4 in the connective tissue, IL-10 in the epithelium and IL-1 in the connective tissue, and IL-1 in the epithelium and IL-10 in the connective tissue. Conclusion: Increased levels of IL-10 and decreased levels of IL-1 show the balance between anti- and pro-inflammatory tissue responses. A significant amount of HBD-2 in the epithelium proves its important role in the local immune response of rosacea-affected tissue. The last effect seems to be intensified by the elevated level of LL-37 in the epithelium.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent2137710
dc.identifier.citationLohova, E, Pilmane, M, Rone-Kupfere, M & Kisis, J 2020, 'Characterization of Pro- and Anti-Inflammatory Tissue Factors in Rosacea : A Pilot study', Cosmetics, vol. 7, no. 4, 82, pp. 1-10. https://doi.org/10.3390/cosmetics7040082
dc.identifier.doi10.3390/cosmetics7040082
dc.identifier.issn2079-9284
dc.identifier.otherMendeley: 46f49c13-71f9-3447-9a45-54357f4b34ee
dc.identifier.otherunpaywall: 10.3390/cosmetics7040082
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6189
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85096226107&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCosmetics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectinflammatory mediators
dc.subjectfacial skin
dc.subjectrosacea
dc.subjectimmune response
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleCharacterization of Pro- and Anti-Inflammatory Tissue Factors in Rosacea : A Pilot studyen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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