Early morphofunctional response of contact tissue after intraosal implantation in rabbit jaw of pure synthetic hydroxyapatite (HAp) bioceramic materials and HAp saturated with lidocaine

Simple item page
dc.contributor.authorSalma, Ilze
dc.contributor.authorPilmane, Mara
dc.contributor.authorSkagers, Andrejs
dc.contributor.authorVetra, Janis
dc.contributor.authorSalms, Girts
dc.contributor.authorBerzina-Cimdina, Liga
dc.contributor.authorSerzane, Rita
dc.contributor.institutionDepartment of Oral and Maxillofacial Surgery and Oral Medicine
dc.contributor.institutionInstitute of Anatomy and Anthropology
dc.date.accessioned2021-04-29T09:45:01Z
dc.date.available2021-04-29T09:45:01Z
dc.date.issued2009
dc.description.abstractPURPOSE: The aim of this study was to evaluate early morphofunctional response of contact tissue to pure and saturated with lidocaine porous synthetic HAp ceramic implants inserted in holes of rabbit upper jaw. MATERIALS AND METHODS: Pure and saturated with lidocaine cylinders of porous HAp ceramics produced at Biomaterials R&D Laboratory of Riga Technical University were inserted into edentulous part of the upper jaw of 12 New Zealand male rabbits. After two weeks, blocks of soft tissue and bone were taken out. The sections done with EXACT Grunding system and from paraffin blocks were stained with haematoxylin/eosin and by use of biotin-streptavidin immunohistochemistry for transforming growth factor beta1 (TGFbeta1), fibroblast growth factor receptor 1 (FGFR1), interleukin 10 (IL10). Apoptosis was detected by TUNEL method. RESULTS: TGFbeta1 was equally expressed in the bone around HAp implants saturated with lidocaine and without lidocaine, while control sections did not show any expression of TGFbeta. In contacting bone tissue to pure HAp and HAp saturated with lidocaine as well in controls rich expression of FGFR1 was observed. In soft tissue of experimental samples also rich expression of FGFR1 was observed, although it was weak in control samples. IL10 had rich expression in all samples. The mean number of apoptotic cells was higher in samples with pure HAp, slightly decreased in samples HAp with lidocaine and significantly lower in controls. CONCLUSIONS: The expression of TGF beta1 confirms osteoinductive activity of HAp. Contact soft tissue to HAp showed rich FGFR1 expression, and weak in controls suggesting higher plasticity of connective tissue to implants in comparison with supportive tissue. Slightly lower apoptosis in samples of HAp with lidocaine gives evidence of indistinct influence of saturated with lidocaine HAp implants on development of programmed cell death.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent423775
dc.identifier.citationSalma, I, Pilmane, M, Skagers, A, Vetra, J, Salms, G, Berzina-Cimdina, L & Serzane, R 2009, 'Early morphofunctional response of contact tissue after intraosal implantation in rabbit jaw of pure synthetic hydroxyapatite (HAp) bioceramic materials and HAp saturated with lidocaine', Stomatologija / issued by public institution "Odontologijos studija" ... [et al.], vol. 11, no. 4, pp. 113-118.
dc.identifier.issn1392-8589
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3986
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77951221806&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofStomatologija / issued by public institution "Odontologijos studija" ... [et al.]
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectimplantation of hydroxyapatite in bone
dc.subjectlidocaine
dc.subjecttransforming growth factor b
dc.subjectfibroblast growth factor receptor
dc.subjectinterleukin 10
dc.subjectapoptosis
dc.subject3.1 Basic medicine
dc.subject3.2 Clinical medicine
dc.subject2.3 Mechanical engineering
dc.subject2.5 Materials engineering
dc.subject2.6 Medical engineering
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Medicine
dc.titleEarly morphofunctional response of contact tissue after intraosal implantation in rabbit jaw of pure synthetic hydroxyapatite (HAp) bioceramic materials and HAp saturated with lidocaineen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Early_morphofunctional_response_of_contact_tissue_1_.pdf
Size:
413.84 KB
Format:
Adobe Portable Document Format
Download

Collections

Research outputs from Pure / Zinātniskās darbības rezultāti no ZDIS Pure