Clinical Impact and Relevance of Antiganglioside Antibodies Test Results

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dc.contributor.authorĶēniņa, Viktorija
dc.contributor.authorGālzere, Ieva
dc.contributor.authorZiemele, Dace
dc.contributor.authorJaunalksne, Inta
dc.contributor.institutionDepartment of Neurology and Neurosurgery
dc.date.accessioned2021-07-01T07:30:01Z
dc.date.available2021-07-01T07:30:01Z
dc.date.issued2015-09-01
dc.descriptionPublisher Copyright: © 2015 by Viktorija keniną.
dc.description.abstractAutoantibodies most commonly found in association with neuropathies are those against the ganglioside family antigens-GM1, GQ1b, asialo-GM1, GM2, GD1a, and GD1b. The major diagnostic role is set for two of antibodies-anti-GM1 and anti-GQ1b. This retrospective study was designed to evaluate the status of antiganglioside antibodies in patients with possible autoimmune neuropathy. The study included 85 patients tested for antiganglioside antibodies during their hospitalization. Clinical information such as demographic data and antecedent illness was collected for all patients, and paraclinical studies including results from cerebrospinal fluid and neuroelectrophysiological examination were analyzed. In our study, a total of 27 patients (32%) were found positive for at least one antiganglioside antibody. The most commonly found antibodies were against asialoGM1 (n=13) and GM1 (n=10) gangliosides. Eight patients were diagnosed with a disease where antiganglioside antibodies are used as a diagnostic marker: five patients-Guillain-Barré syndrome (GBS), 1 patient-Miller-Fisher syndrome (MFS), two patients-multifocal motor neuropathy (MMN). Three out of five patients diagnosed with GBS and one of two patients diagnosed with MMN were seronegative. The acute course of disease, positive antiganglioside antibodies and cytoalbuminologic dissociation in cerebrospinal fluid-induced patients is preference for a specific immune therapy. The results of our study support the previously described immunological association between antiganglioside antibodies and GBS, MFS, and MMN.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.format.extent215324
dc.identifier.citationĶēniņa, V, Gālzere, I, Ziemele, D & Jaunalksne, I 2015, 'Clinical Impact and Relevance of Antiganglioside Antibodies Test Results', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 69, no. 5, pp. 223-227. https://doi.org/10.1515/prolas-2015-0033
dc.identifier.doi10.1515/prolas-2015-0033
dc.identifier.issn1407-009X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5779
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84948124412&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectautoimmune neuropathy
dc.subjectcytoalbuminologic dissociation
dc.subjectgangliosides
dc.subjectGuillain-Barré syndrome
dc.subjectMiller-Fisher syndrome
dc.subjectmultifocal motor neuropathy
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral
dc.titleClinical Impact and Relevance of Antiganglioside Antibodies Test Resultsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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