Coverage with timely administered vaccination against hepatitis b virus and its influence on the prevalence of HBV infection in the regions of different endemicity

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dc.contributor.authorKyuregyan, Karen K.
dc.contributor.authorKichatova, Vera S.
dc.contributor.authorIsaeva, Olga V.
dc.contributor.authorPotemkin, Ilya A.
dc.contributor.authorMalinnikova, Elena Yu
dc.contributor.authorLopatukhina, Maria A.
dc.contributor.authorKarlsen, Anastasia A.
dc.contributor.authorMobarhan, Fedor A.Asadi
dc.contributor.authorMullin, Eugeniy V.
dc.contributor.authorSlukinova, Olga S.
dc.contributor.authorIgnateva, Margarita E.
dc.contributor.authorSleptsova, Snezhana S.
dc.contributor.authorOglezneva, Elena E.
dc.contributor.authorShibrik, Elena V.
dc.contributor.authorIsaguliants, Maria G.
dc.contributor.authorMikhailov, Mikhail I.
dc.contributor.institutionResearch Department
dc.date.accessioned2021-04-09T10:35:01Z
dc.date.available2021-04-09T10:35:01Z
dc.date.issued2021-01-23
dc.descriptionFunding Information: Funding: This research was funded by grant of the Russian Science Foundation (ID-20-15-00148). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractUniversal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population. Here, we assessed the timely coverage of newborns with the birth dose (HepB-BD), second dose (HepB-2nd), and three vaccine doses (HepB3) in two remote regions of Russia with low (Belgorod Oblast) and high (Yakutia) levels of hepatitis B virus (HBV) endemicity. Vaccination data were obtained from the medical records of 1000 children in Yakutia and 2182 children in Belgorod Oblast. Sera of healthy volunteers from Belgorod Oblast (n = 1754) and Yakutia (n = 1072) across all age groups were tested for serological markers of HBV to assess the infection prevalence and herd immunity. Average HepB-BD coverage was 99.2% in Yakutia and 89.4% in Belgorod Oblast (p < 0.0001) and in both regions varied significantly, from 66% to 100%, between medical centers. The principal reason for the absence of HepB-BD was parent refusal, which accounted for 63.5% of cases of non-vaccination (83/123). While timely HepB-2nd coverage was only 55.4%–64.7%: HepB3 coverage by the age of one year exceeded 90% in both study regions. HBV surface antigen (HBsAg) prevalence in the 1998–2019 birth cohort was 0.2% (95% CI: 0.01–1.3%) in Belgorod Oblast and 3.2% (95% CI: 1.9–5.2%) in Yakutia. The proportion of persons testing negative for both antibodies to HBsAg (anti-HBs) and antibodies to HBV core antigen (anti-HBc) in the 1998–2019 birth cohort was 26.2% (125/481) in Belgorod Oblast and 32.3% (162/501) in Yakutia. We also assessed the knowledge of and attitude towards vaccination among 782 students and teachers of both medical and non-medical specialties from Belgorod State University. Only 60% of medical students knew that hepatitis B is a vaccine-preventable disease. Both medical and nonmedical students, 37.8% and 31.3%, respectively, expressed concerns about safety and actual necessity of vaccination. These data indicate the need to introduce a vaccine delivery audit system, improve medical education with respect to vaccination strategies and policies, and reinforce public knowledge on the benefits of vaccination.en
dc.description.statusPeer reviewed
dc.format.extent15
dc.format.extent927334
dc.identifier.citationKyuregyan, K K, Kichatova, V S, Isaeva, O V, Potemkin, I A, Malinnikova, E Y, Lopatukhina, M A, Karlsen, A A, Mobarhan, F A A, Mullin, E V, Slukinova, O S, Ignateva, M E, Sleptsova, S S, Oglezneva, E E, Shibrik, E V, Isaguliants, M G & Mikhailov, M I 2021, 'Coverage with timely administered vaccination against hepatitis b virus and its influence on the prevalence of HBV infection in the regions of different endemicity', Vaccines, vol. 9, no. 2, 82, pp. 1-15. https://doi.org/10.3390/vaccines9020082
dc.identifier.doi10.3390/vaccines9020082
dc.identifier.issn2076-393X
dc.identifier.otherunpaywall: 10.3390/vaccines9020082
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/3723
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85099946018&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofVaccines
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBirth dose coverage
dc.subjectHBV prevalence
dc.subjectHepatitis B epidemiology
dc.subjectHepatitis B vaccine
dc.subjectPublic health
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectImmunology
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.subjectInfectious Diseases
dc.subjectPharmacology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCoverage with timely administered vaccination against hepatitis b virus and its influence on the prevalence of HBV infection in the regions of different endemicityen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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