Successful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection

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dc.contributor.authorRacenis, Karlis
dc.contributor.authorLacis, Janis
dc.contributor.authorRezevska, Dace
dc.contributor.authorMukane, Laima
dc.contributor.authorVilde, Aija
dc.contributor.authorPutnins, Ints
dc.contributor.authorDjebara, Sarah
dc.contributor.authorMerabishvili, Maya
dc.contributor.authorPirnay, Jean Paul
dc.contributor.authorKalnina, Marika
dc.contributor.authorPetersons, Aivars
dc.contributor.authorStradins, Peteris
dc.contributor.authorMaurins, Sandis
dc.contributor.authorKroica, Juta
dc.contributor.institutionDepartment of Biology and Microbiology
dc.contributor.institutionDepartment of Internal Diseases
dc.contributor.institutionDepartment of Surgery
dc.date.accessioned2023-06-30T11:55:01Z
dc.date.available2023-06-30T11:55:01Z
dc.date.issued2023-05
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractThere is considerable interest in the use of bacteriophages (phages) to treat Pseudomonas aeruginosa infections associated with left ventricular assist devices (LVADs). These infections are often challenging to manage due to high rates of multidrug resistance and biofilm formation, which could potentially be overcome with the use of phages. We report a case of a 54-year-old man with relapsing multidrug-resistant P. aeruginosa LVAD driveline infection, who was treated with a combination of two lytic antipseudomonal phages administered intravenously and locally. Treatment was combined with LVAD driveline repositioning and systemic antibiotic administration, resulting in a successful outcome with clinical cure and eradication of the targeted bacteria. However, laboratory in vitro models showed that phages alone could not eradicate biofilms but could prevent biofilm formation. Phage-resistant bacterial strains evolved in biofilm models and showed decreased susceptibility to the phages used. Further studies are needed to understand the complexity of phage resistance and the interaction of phages and antibiotics. Our results indicate that the combination of phages, antibiotics, and surgical intervention can have great potential in treating LVAD-associated infections. More than 21 months post-treatment, our patient remains cured of the infection.en
dc.description.statusPeer reviewed
dc.format.extent15
dc.format.extent3672078
dc.identifier.citationRacenis, K, Lacis, J, Rezevska, D, Mukane, L, Vilde, A, Putnins, I, Djebara, S, Merabishvili, M, Pirnay, J P, Kalnina, M, Petersons, A, Stradins, P, Maurins, S & Kroica, J 2023, 'Successful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection', Viruses, vol. 15, no. 5, 1210. https://doi.org/10.3390/v15051210
dc.identifier.doi10.3390/v15051210
dc.identifier.issn1999-4915
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/12707
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85160375095&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofViruses
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiofilm
dc.subjectcase report
dc.subjectLVAD infection
dc.subjectmultidrug resistance
dc.subjectPET/CT
dc.subjectphage resistance
dc.subjectphage therapy
dc.subject3.1 Basic medicine
dc.subject3.3 Health sciences
dc.subject1.6 Biological sciences
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectInfectious Diseases
dc.subjectVirology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleSuccessful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infectionen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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