Perfusion computed tomography relative threshold values in definition of acute stroke lesions

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dc.contributor.authorRadzina, Maija
dc.contributor.authorKrumina, Gaida
dc.contributor.authorKupcs, Karlis
dc.contributor.authorMiglāne, Evija
dc.contributor.institutionDepartment of Radiology
dc.date.accessioned2021-11-22T09:35:01Z
dc.date.available2021-11-22T09:35:01Z
dc.date.issued2013-04-01
dc.description.abstractBACKGROUND: Perfusion computed tomography (CT) is a relatively new technique that allows fast evaluation of cerebral hemodynamics by providing perfusion maps and gives confirmation of perfusion deficits in ischemic areas. Some controversies exist regarding accuracy of quantitative detection of tissue viability: penumbra (tissue at risk) or core (necrosis). PURPOSE: To define brain tissue viability grade on the basis of the perfusion CT parameters in acute stroke patients. MATERIAL AND METHODS: A multimodal CT imaging protocol; unenhanced CT of the brain, CT angiography of head and neck blood vessels, followed by brain perfusion CT and 24 h follow-up brain CT was performed. Perfusion deficits were detected first visually, with subsequent manual quantitative and relative measurements in affected and contra-lateral hemisphere in 87 acute stroke patients. RESULTS: Visual perfusion deficit on perfusion CT images was found in 78 cases (38 women, 40 men; mean age, 30-84 years). Penumbra lesions (n = 49) and core lesions (n = 42) were detected by increased mean transit time (MTT) on perfusion CT maps in comparison to contra-lateral hemispheres. Cerebral blood volume (CBV) mean values in the penumbra group were increased in the penumbra group and decreased in the core group. Cerebral blood flow (CBF) values were decreased in penumbra and markedly decreased in core lesion. CONCLUSION: Perfusion CT measurements are reliable in estimation of penumbra and core lesions in acute stroke patients, if relative threshold values are used. The most accurate parameter of hypoperfusion is increased MTT above 190%. Relative threshold values for irreversible lesion are CBFen
dc.description.statusPeer reviewed
dc.format.extent101524
dc.identifier.citationRadzina, M, Krumina, G, Kupcs, K & Miglāne, E 2013, 'Perfusion computed tomography relative threshold values in definition of acute stroke lesions', Acta Radiologica Short Reports, vol. 2, no. 3, pp. 1-3. https://doi.org/10.1177/2047981613486099
dc.identifier.doi10.1177/2047981613486099
dc.identifier.issn2047-9816
dc.identifier.otherMendeley: ea443883-c21f-3e79-b895-af483ba9c23b
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/6853
dc.identifier.urlhttps://www.mendeley.com/catalogue/ea443883-c21f-3e79-b895-af483ba9c23b/
dc.language.isoeng
dc.relation.ispartofActa Radiologica Short Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComputed tomography
dc.subjectperfusion
dc.subjectstroke
dc.subject3.2 Clinical medicine
dc.subject1.3. Anonymously reviewed scientific article published in a journal with an international editorial board and is available in another indexed database
dc.titlePerfusion computed tomography relative threshold values in definition of acute stroke lesionsen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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