Microbiota Assessment of Pediatric Simple and Complex Acute Appendicitis

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dc.contributor.authorKakar, Mohit
dc.contributor.authorReinis, Aigars
dc.contributor.authorKroiča, Juta
dc.contributor.authorEņģelis, Arnis
dc.contributor.authorBroks, Renārs
dc.contributor.authorAsare, Lāsma
dc.contributor.authorVermeulen, Marelize
dc.contributor.authorSenica, Simone Oliver
dc.contributor.authorSaxena, Amulya
dc.contributor.authorPētersons, Aigars
dc.contributor.institutionDepartment of Paediatric Surgery
dc.contributor.institutionDepartment of Biology and Microbiology
dc.contributor.institutionStatistics Unit
dc.date.accessioned2022-09-28T09:35:02Z
dc.date.available2022-09-28T09:35:02Z
dc.date.issued2022-09
dc.descriptionFunding Information: This study was funded by Latvian Academy of Science and Riga Stradins University. Publisher Copyright: © 2022 by the authors.
dc.description.abstractBackground and Objectives. The aim of this study is to determine the prevailing microbiota in samples from pediatric patients with acute appendicitis, as well as evaluate the antibacterial sensitivity of the isolated microorganisms, comparing the data obtained with the clinic's antibacterial therapy guidelines. Materials and Methods. The study group consisted of 93 patients between the ages of 7 and 18. All patients underwent a laparoscopic or conventional appendectomy. The children were hospitalized with signs and symptoms suggestive of acute appendicitis. Microbiological cultures from the appendix and abdominal cavity were collected intraoperatively. Results. E. coli was identified in most cases irrespective of the clinical presentation of acute appendicitis. Most strains were susceptible to ampicillin and amoxicillin/clavulanic acid. Five strains of E. coli produced extended spectrum beta-lactamase (ESBL). Pseudomonas aeruginosa (P. aeruginosa) was the second most commonly isolated causative agent. Furthermore, it was common in cases of acute complex appendicitis. Most strains of P. aeruginosa were resistant to amoxicillin/clavulanic acid, ertapenem, ampicillin and cefotaxime, yet were susceptible to ceftazidime. Regardless of the clinical presentation, the samples yielded mixed isolates. Conclusion. E. coli is the main causative agent of acute appendicitis in the pediatric population displaying susceptibility to various antibiotics. P. aeruginosa was more prevalent in cases of acute complex appendicitis. P. aeruginosa isolates were susceptible to ceftazidime; however, they were resistant to cefotaxime, which should, therefore, be removed from guidelines for empirical antibacterial treatment of acute appendicitis due to phenotypic resistance of P. aeruginosa. We recommend antibiotics with distinct implementation to avoid antibiotic resistance.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent323659
dc.identifier.citationKakar, M, Reinis, A, Kroiča, J, Eņģelis, A, Broks, R, Asare, L, Vermeulen, M, Senica, S O, Saxena, A & Pētersons, A 2022, 'Microbiota Assessment of Pediatric Simple and Complex Acute Appendicitis', Medicina (Kaunas, Lithuania), vol. 58, no. 9, 1144, pp. 1144. https://doi.org/10.3390/medicina58091144
dc.identifier.doi10.3390/medicina58091144
dc.identifier.issn1010-660X
dc.identifier.otherMendeley: 086e14b1-08af-32ce-a485-32e976987f9b
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9586
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85138415938&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofMedicina (Kaunas, Lithuania)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdolescent
dc.subjectAmoxicillin-Potassium Clavulanate Combination/pharmacology
dc.subjectAnti-Bacterial Agents/pharmacology
dc.subjectAppendicitis/surgery
dc.subjectCefotaxime/therapeutic use
dc.subjectCeftazidime/therapeutic use
dc.subjectChild
dc.subjectErtapenem/therapeutic use
dc.subjectEscherichia coli
dc.subjectHumans
dc.subjectMicrobiota
dc.subjectPseudomonas aeruginosa
dc.subjectbeta-Lactamases/therapeutic use
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.titleMicrobiota Assessment of Pediatric Simple and Complex Acute Appendicitisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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