Biomarker combinations in predicting sepsis in hospitalized children with fever

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dc.contributor.authorRautiainen, Linda
dc.contributor.authorCirko, Anna
dc.contributor.authorPavare, Jana
dc.contributor.authorGrope, Ilze
dc.contributor.authorGersone, Gita
dc.contributor.authorTretjakovs, Peteris
dc.contributor.authorGardovska, Dace
dc.contributor.institutionDepartment of Paediatrics
dc.contributor.institutionDepartment of Human Physiology and Biochemistry
dc.date.accessioned2022-11-17T10:50:01Z
dc.date.available2022-11-17T10:50:01Z
dc.date.issued2022-12
dc.descriptionFunding Information: This study was conducted as a part of the Republic of Latvia “State Research Program VPP BIOMEDICINE” Project No 8.2 „Clinical, molecular-biological and morpho-functional research of diagnostics and treatment of inherited and acquired diseases of childhood”. Funding Information: This study was also partially funded by “The Latvian National Research Program BIOMEDICINE FOR PUBLIC HEALTH”, project No 6. Publisher Copyright: © 2022, The Author(s).
dc.description.abstractSepsis is among the leading causes of critical illness worldwide. It includes physiologic, pathologic, and biochemical abnormalities, induced by infection. Novel methods for recognizing a dysregulated inflammatory response and predicting associated mortality must be developed. Our aim was to investigate biomarkers that characterize a pro-inflammatory and anti-inflammatory response in patients with fever by comparing predictive validity for sepsis. 165 patients with fever were enrolled in this study, 55 of them had sepsis according to pSOFA criteria. All patients had blood samples drawn at the time of inclusion and after 24 h. CRP, PCT and also IL-6, IL-8 and sFAS levels were significantly higher in patients with sepsis. The AUC of CRP to predict sepsis was 0.799, all the other biomarkers had AUC’s lower than that. Cytokines, when used as a single marker, did not show a significant diagnostic performance We analyzed various models of biomarker combinations. CRP combined with sFAS showed increase in sensitivity in predicting sepsis (88% vs. 83%). The highest AUC was achieved, when CRP, IL-6, sFAS and sVCAM-1 markers were combined 0.830 (95% CI 0.762–0.884) with a sensitivity of 70% and specificity of 84%. vs. 0.799 for CRP alone.en
dc.description.statusPeer reviewed
dc.format.extent10
dc.format.extent2924442
dc.identifier.citationRautiainen, L, Cirko, A, Pavare, J, Grope, I, Gersone, G, Tretjakovs, P & Gardovska, D 2022, 'Biomarker combinations in predicting sepsis in hospitalized children with fever', BMC Pediatrics, vol. 22, no. 1, 272. https://doi.org/10.1186/s12887-022-03285-3
dc.identifier.doi10.1186/s12887-022-03285-3
dc.identifier.issn1471-2431
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/9790
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85130632614&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofBMC Pediatrics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomarker
dc.subjectCytokine
dc.subjectFever
dc.subjectPediatric
dc.subjectSepsis
dc.subject3.2 Clinical medicine
dc.subject3.1 Basic medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectPediatrics, Perinatology, and Child Health
dc.titleBiomarker combinations in predicting sepsis in hospitalized children with feveren
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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