Dislipidēmijas pacientu uztura bagātinātāju lietošanas paradumu drošums.
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Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Praškilēvics A., (2020) Dislipidēmijas pacientu uztura bagātinātāju lietošanas paradumu drošums. Pētnieciskais darbs. Zinātniskā vadītāja asistenta p.i., Dipl.pharm. Viktorija Joņina. Rīgas Stradiņa universitāte. Darba pamatteksts sastāv no 28 lapaspusēm, 4 pielikumiem, 8 tabulām, 5 attēliem un 30 bibliogrāfijas nosaukumiem latviešu un angļu valodā.
Ateroskleroze un sirds išēmiskā slimība ir biežākie priekšlaicīgas nāves cēloņi Eiropā. Pieaugot holesterīna vielmaiņas traucējumu prevalencei, kļūst lielāks arī to pacientu loks, kuri saņem holesterīnu pazeminošo medikamentu terapiju. Ja pacients lieto arī uztura bagātinātājus, palielinās risks iespējamām zāļu-uztura bagātinātāju mijiedarbībām, kas var apdraudēt pacienta veselību. Pētījuma mērķis ir identificēt un analizēt iespējamos riskus uztura bagātinātāju mijiedarbībai ar hipolipidemizējošo terapiju dislipidēmijas pacientiem Latvijā. Pētniecisko darbu veido 2 daļas – literatūras apskats un pētnieciskā daļa. Literatūras apskatā tiek apkopota informācija par dislipidēmijas ārstēšanas farmakoterapiju, statīnu iespējamiem mijiedarbību mehānismiem ar uztura bagātinātājiem un detalizēti aprakstītas uztura bagātinātājos esošās dabas vielas un komponentes, ar kurām ir mijiedarbību riski. Pētnieciskajā daļā tiek apkopoti 100 anketu rezultāti ar pacientu datiem par uztura bagātinātāju lietošanas paradumiem, vienlaikus saņemot hipolipidemizējošo terapiju. Latvijas Uztura bagatinātāju reģistrā ir konstatēti produkti, kuriem ir mijiedarbību riski ar statīniem. Darba ietvaros ir identificētas dabas vielas ar augstāko mijiedarbību risku pacientiem, kas saņem statīnu terapiju Latvijā.
Praškilēvics A., The safety of habits of food supplementation use in dyslipidemic patients. Research work. Scientific supervisor acting assistant Viktorija Joņina. Riga Stradiņš University. The work consists of 28 pages, 4 attachments, 8 tables, 5 figures and 30 bibliographic sources in Latvian and English. Atherosclerosis and ischemic heart disease are the most common causes of premature death in Europe. As the prevalence of cholesterol metabolism disorders increases, so does the number of patients receiving cholesterol-lowering medications. If a patient is also taking food supplements, there is an increased risk of possible drug-supplement interactions that could endanger the patients' health. The aim of the study is to identify and analyze the possible risks of the interaction of food supplements with hypolipidemic therapy in dyslipidemic patients in Latvia. The research work consists of 2 parts: literature review and research part. The literature review summarizes information on pharmacotherapy for the treatment of dyslipidemia, possible mechanisms of interactions of statins with food supplements, and describes in details the natural substances and components in food supplements with which there are risks of interactions. The research part summarizes the results of 100 questionnaires with patient data on the use of food supplements while receiving hypolipidemic therapy. In the research part, the analysis of the amount of food supplements found in the Latvian Register of Food Supplements, which have risks of interactions with statins, was performed. Within the framework of the work, natural substances with the highest risk of interactions have been identified for patients receiving statin therapy in Latvia.
Praškilēvics A., The safety of habits of food supplementation use in dyslipidemic patients. Research work. Scientific supervisor acting assistant Viktorija Joņina. Riga Stradiņš University. The work consists of 28 pages, 4 attachments, 8 tables, 5 figures and 30 bibliographic sources in Latvian and English. Atherosclerosis and ischemic heart disease are the most common causes of premature death in Europe. As the prevalence of cholesterol metabolism disorders increases, so does the number of patients receiving cholesterol-lowering medications. If a patient is also taking food supplements, there is an increased risk of possible drug-supplement interactions that could endanger the patients' health. The aim of the study is to identify and analyze the possible risks of the interaction of food supplements with hypolipidemic therapy in dyslipidemic patients in Latvia. The research work consists of 2 parts: literature review and research part. The literature review summarizes information on pharmacotherapy for the treatment of dyslipidemia, possible mechanisms of interactions of statins with food supplements, and describes in details the natural substances and components in food supplements with which there are risks of interactions. The research part summarizes the results of 100 questionnaires with patient data on the use of food supplements while receiving hypolipidemic therapy. In the research part, the analysis of the amount of food supplements found in the Latvian Register of Food Supplements, which have risks of interactions with statins, was performed. Within the framework of the work, natural substances with the highest risk of interactions have been identified for patients receiving statin therapy in Latvia.
Description
Farmācija
Pharmacy
Veselības aprūpe
Health Care
Pharmacy
Veselības aprūpe
Health Care
Keywords
statīni, uztura bagātinātāji, augu-uztura bagātinātāju mijiedarbības, augu-zāļu mijiedarbības, statīnu metabolizētāji, statīnu transportsistēmas, BCRP, CYP sistēmas, OATP transportieri, P-glikoproteīni, statins, food supplements, herb-statin interactions, herb-drug interactions, statin metabolizers, statin transporter systems, BCRP, CYP systems, OATP transporters, P-glycoproteins