Labvēlīga Vidusjūras diētas ietekme uz nealkohola steatohepatozi.
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Date
2022
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Rīgas Stradiņa universitāte
Rīga Stradiņš University
Rīga Stradiņš University
Abstract
Pētnieciskā darba tēma ir Labvēlīga Vidusjūras diētas ietekme uz nealkohola steatohepatozi. Autors uzskata, ka mūsdienās ir nesamērīgais olbaltumvielu, ogļhidrātu, tauku un šķiedrvielu uzturs, kas populācijā rada nopietnus riskus steatohepatozes attīstībai. Autors centās noskaidrot, vai Vidusjūras diēta palīdz izvairīties no steatohepatozes attīstības. Izvirzītie darba uzdevumi bija - Noskaidrot VD (Vidusjūras diētas) pamatprincipus, Noformulēt zinātnē balstītu viedokli un izpratni par Vidusjūras diētas nozīmīgumu un ietekmi uz nealkohola steatohepatozi, Kritiski novērtēt, vai pacienti, kuri ievēro citus ēšanas paradumus, piemēram, diētu ar augstāku piesātināto taukskābju saturu, ticami biežāk slimo ar steatohepatozi, Analizēt ieguvumus, ievērojot Vidusjūras diētu. Interpretēt citu autoru iegūtos datus par VD pozitīvo ietekmi uz nealkohola aknu steatohepatozes attīstību. Noskaidrot, vai VD ievērošana ar steatohepatozi slimojošu pacientu vidū ietekmē negatīvu slimības iznākumu. Darba hipotēze: cilvēks, kurš uzturā lieto Vidusjūras diētu, ir mazāk pakļauts steatohepatozes attīstības riskam. Darbs tika veidots, kā argumentējošs literatūras apskats un citu autoru atziņu sistematizēšana. Pētījumos diētu modifikācijas un pielietošanas ilgums atšķīrās. Autors, veidojot šo literatūras pārskatu, datus, pētījumus un zinātnisko literatūru meklēja tādās datubāzēs kā Pubmed, Scopus, UpToDate, izmantojot tulkotus atslēgas vārdus kā Non alchoholic hepatosteatosis, Mediterranean diet un steatohepatosis. Tika apkopoti pēc iespējas aktuālāki pētījumi un citu autoru secinājumi. Veicot šo literatūras apskatu, autors kopumā izvērtēja 62 avotus, tika iekļauta zinātniskā literatūra un publikācijas. Metaanalīzei sākotnēji tika apskatīti 57 pētījumi, no kuriem tālāk, vērtējot pēc atlases kritērijiem, tika atlasīti 18 pētījumi, bet metaanalīzē tika iekļauti 9 pētījumi, kuri atbilda autora izvirzītajiem atlases kritērijiem. Pētījumiem bija jābūt ne vecākiem par 15 gadiem, līdz ar to tika izvēlēti pētījumi laika posmā 2008. – 2021. gadam. Tika izslēgti tādi pētījumi, kuros pētāmā populācija nebija cilvēki un bija mazāka vai vienāda ar n 10. Netika iekļauti pētījumi, kuros piedalījās grūtnieces un cilvēki, kuri nebija sasnieguši 18 gadu vecumu. Autors secina, ka izvirzītā darba hipotēze apstiprinājās, respektīvi cilvēki, kuri ievēroja VD tika mazāk pakļauti NATAS attīstībai un slimības progresam. Pierādījās, ka diēta ar augstāku ABL –C saturu mazina NATAS attīstību un kopumā tam bija labāka ietekme uz lipīdu profilu, pēc pētījuma datiem priekšroka dodama aukstākā labuma olīveļļas un taukvielu, ko satur rieksti, izvēlei. Ieguvumu deva arī dzīvnieku izcelsmes taukvielu ierobežošana. Lipīdu, ĶMI un aknu bioķīmisko rādītāju, vērā ņemams samazinājums bija pēc vismaz 6 mēnešu precīzas (MDS ≥6) VD ievērošanas. Pacientiem, krui slimoja ar NATAS, pēc VD ievērošanas bija vērā ņemams lipīdu profila, glikozes līmeņa, insulīna jūtības, aknu bioķīmisko rādītāju un ĶMI uzlabojums.
Research topic is Beneficial effects of the Mediterranean diet on non-alchoholic liver steatohepatosis. In author’s opinion the disproportionate diet of proteins, carbohydrates, fats and fiber poses are serious risks to the development of steatohepatosis. Author tries to find out how the Mediterranean diet helps to prevent the development of steatohepatosis. Tasks: To find out the basic principles of MD (Mediterranean diet). To formulate a science-based view of the importance and impact of the Mediterranean diet on liver disease. Critically assess if patients who follow other eating habits, such as a diet with high amount of fatty acids, are more likely to have risks to develop steatohepatosis. To analyze the benefits of following a editerranean diet. To interpret the data obtained by other authors on the positive effect of MD on the development of non-alcoholic liver steatohepatosis. To find out if MD in patients with steatohepatosis affects the outcome of the disease. Hypothesis: A person who consumes a MD has a lower risk of developing non – alchoholic steatohepatosis. Research was made as Literature review. Systematization of the other author’s findings. Modifications and duration of the diet interventions were different in the studies. The author used databases such as Pubmed, Scopus, UpToDate, for searching used keywords such as Non alchoholic hepatosteatosis, Mediterranean diet and steatohepatosis. Were summarized the most relevant research and conclusions of other authors. In this literature review, the author estimate a total of 62 sources, including scientific literature and publications. 57 studies were examined for meta-analysis, of which 18 studies were further selected for evaluation according to the selection criteria, but 9 studies were included in the meta-analysis. The studies had to be no older than 15 years and were selected for the period 2008-2021. Studies in which the population was non-human and less than or equal to n10 were excluded. Studies in pregnant women and people under 18 years of age were not included. The author concludes that the hypothesis of the proposed work is confirmed, respectively, that people who adhere to MD are less likely to develop and progress of NAFLD. It is important that more accurate compliance of the MD is associated with a lower risk of NAFLD. In the literature review, evidence that a diet with a higher HDL-C content reduces the development of NAFLD and generally has a better effect on the lipid profile, the study data shows benefits of choosing extra virgin olive oil and nuts. Decreaseing an animal fats in diet also has benefits. Studies had been shown significant decrease of lipid, BMI, and hepatic biochemistry levels, after taking adecvat diet at least 6 months - (MDS ≥6). Overall after MD diet intervences lipid profile, glucose level, insulin sensation, has shown improvement in liver biochemistry and BMI, as well as reduction in the prevalence of heosteatosis in patients with NAFLD.
Research topic is Beneficial effects of the Mediterranean diet on non-alchoholic liver steatohepatosis. In author’s opinion the disproportionate diet of proteins, carbohydrates, fats and fiber poses are serious risks to the development of steatohepatosis. Author tries to find out how the Mediterranean diet helps to prevent the development of steatohepatosis. Tasks: To find out the basic principles of MD (Mediterranean diet). To formulate a science-based view of the importance and impact of the Mediterranean diet on liver disease. Critically assess if patients who follow other eating habits, such as a diet with high amount of fatty acids, are more likely to have risks to develop steatohepatosis. To analyze the benefits of following a editerranean diet. To interpret the data obtained by other authors on the positive effect of MD on the development of non-alcoholic liver steatohepatosis. To find out if MD in patients with steatohepatosis affects the outcome of the disease. Hypothesis: A person who consumes a MD has a lower risk of developing non – alchoholic steatohepatosis. Research was made as Literature review. Systematization of the other author’s findings. Modifications and duration of the diet interventions were different in the studies. The author used databases such as Pubmed, Scopus, UpToDate, for searching used keywords such as Non alchoholic hepatosteatosis, Mediterranean diet and steatohepatosis. Were summarized the most relevant research and conclusions of other authors. In this literature review, the author estimate a total of 62 sources, including scientific literature and publications. 57 studies were examined for meta-analysis, of which 18 studies were further selected for evaluation according to the selection criteria, but 9 studies were included in the meta-analysis. The studies had to be no older than 15 years and were selected for the period 2008-2021. Studies in which the population was non-human and less than or equal to n10 were excluded. Studies in pregnant women and people under 18 years of age were not included. The author concludes that the hypothesis of the proposed work is confirmed, respectively, that people who adhere to MD are less likely to develop and progress of NAFLD. It is important that more accurate compliance of the MD is associated with a lower risk of NAFLD. In the literature review, evidence that a diet with a higher HDL-C content reduces the development of NAFLD and generally has a better effect on the lipid profile, the study data shows benefits of choosing extra virgin olive oil and nuts. Decreaseing an animal fats in diet also has benefits. Studies had been shown significant decrease of lipid, BMI, and hepatic biochemistry levels, after taking adecvat diet at least 6 months - (MDS ≥6). Overall after MD diet intervences lipid profile, glucose level, insulin sensation, has shown improvement in liver biochemistry and BMI, as well as reduction in the prevalence of heosteatosis in patients with NAFLD.
Description
Medicīna
Medicine
Veselības aprūpe
Health Care
Medicine
Veselības aprūpe
Health Care
Keywords
Vidusjūras diēta, ne alkohola steatohepatoze., Mediterranean diet, non – alchoholic steatohepatosis.