Impact of the genes UGT1A1, GSTT1, GSTM1, GSTA1, GSTP1 and NAT2 on acute alcohol-toxic hepatitis

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dc.contributor.authorPiekuse, Linda
dc.contributor.authorLace, Baiba
dc.contributor.authorKreile, Madara
dc.contributor.authorSadovska, Lilite
dc.contributor.authorKempa, Inga
dc.contributor.authorDaneberga, Zanda
dc.contributor.authorMičule, Ieva
dc.contributor.authorSondore, Valentina
dc.contributor.authorKeiss, Jazeps
dc.contributor.authorKrumina, Astrida
dc.contributor.institutionScientific Laboratory of Molecular Genetics
dc.date.accessioned2021-07-01T09:45:01Z
dc.date.available2021-07-01T09:45:01Z
dc.date.issued2014-02
dc.descriptionFunding Information: This study was supported by grants from the Latvian Science Council grant Nos. 09.1384 and 10.0010.02. and the European Social Fund project, which supports the doctoral study program and PhD degree qualification in Riga Stradins University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.description.abstractAlcohol metabolism causes cellular damage by changing the redox status of cells. In this study, we investigated the relationship between genetic markers in genes coding for enzymes involved in cellular redox stabilization and their potential role in the clinical outcome of acute alcohol-induced hepatitis. Study subjects comprised 60 patients with acute alcohol-induced hepatitis. The control group consisted of 122 healthy non-related individuals. Eight genetic markers of the genes UGT1A1, GSTA1, GSTP1, NAT2, GSTT1 and GSTM1 were genotyped. GSTT1 null genotype was identified as a risk allele for alcohol-toxic hepatitis progression (OR 2.146, P=0.013). It was also found to correlate negatively with the level of prothrombin (β= -11.05, P=0.037) and positively with hyaluronic acid (β=170.4, P=0.014). NAT2 gene alleles rs1799929 and rs1799930 showed opposing associations with the activity of the biochemical markers γ-glutamyltransferase and alkaline phosphatase; rs1799929 was negatively correlated with γ-glutamyltransferase (β=-261.3, P=0.018) and alkaline phosphatase (β= -270.5, P=0.032), whereas rs1799930 was positively correlated with Γ-glutamyltransferase (β=325.8, P=0.011) and alkaline phosphatase (β=374.8, P=0.011). Enzymes of the glutathione S-transferase family and NAT2 enzyme play an important role in the detoxification process in the liver and demonstrate an impact on the clinical outcome of acute alcohol-induced hepatitis.en
dc.description.statusPeer reviewed
dc.format.extent6
dc.format.extent379239
dc.identifier.citationPiekuse, L, Lace, B, Kreile, M, Sadovska, L, Kempa, I, Daneberga, Z, Mičule, I, Sondore, V, Keiss, J & Krumina, A 2014, 'Impact of the genes UGT1A1, GSTT1, GSTM1, GSTA1, GSTP1 and NAT2 on acute alcohol-toxic hepatitis', Central European Journal of Biology, vol. 9, no. 2, pp. 125-130. https://doi.org/10.2478/s11535-013-0249-y
dc.identifier.doi10.2478/s11535-013-0249-y
dc.identifier.issn1895-104X
dc.identifier.urihttps://dspace.rsu.lv/jspui/handle/123456789/5787
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84887957121&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCentral European Journal of Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlcoholic
dc.subjectHepatitis
dc.subjectOxidative stress
dc.subjectPharmacogenetics
dc.subject1.6 Biological sciences
dc.subject3.2 Clinical medicine
dc.subject1.1. Scientific article indexed in Web of Science and/or Scopus database
dc.subjectGeneral Neuroscience
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.subjectGeneral Immunology and Microbiology
dc.subjectGeneral Agricultural and Biological Sciences
dc.subjectSDG 3 - Good Health and Well-being
dc.titleImpact of the genes UGT1A1, GSTT1, GSTM1, GSTA1, GSTP1 and NAT2 on acute alcohol-toxic hepatitisen
dc.type/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article

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